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Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents’ survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHR...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715013/ https://www.ncbi.nlm.nih.gov/pubmed/29030599 http://dx.doi.org/10.1038/s41467-017-00934-5 |
| _version_ | 1783283670981804032 |
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| author | Joshi, Peter K. Pirastu, Nicola Kentistou, Katherine A. Fischer, Krista Hofer, Edith Schraut, Katharina E. Clark, David W. Nutile, Teresa Barnes, Catriona L. K. Timmers, Paul R. H. J. Shen, Xia Gandin, Ilaria McDaid, Aaron F. Hansen, Thomas Folkmann Gordon, Scott D. Giulianini, Franco Boutin, Thibaud S. Abdellaoui, Abdel Zhao, Wei Medina-Gomez, Carolina Bartz, Traci M. Trompet, Stella Lange, Leslie A. Raffield, Laura van der Spek, Ashley Galesloot, Tessel E. Proitsi, Petroula Yanek, Lisa R. Bielak, Lawrence F. Payton, Antony Murgia, Federico Concas, Maria Pina Biino, Ginevra Tajuddin, Salman M. Seppälä, Ilkka Amin, Najaf Boerwinkle, Eric Børglum, Anders D. Campbell, Archie Demerath, Ellen W. Demuth, Ilja Faul, Jessica D. Ford, Ian Gialluisi, Alessandro Gögele, Martin Graff, MariaElisa Hingorani, Aroon Hottenga, Jouke-Jan Hougaard, David M. Hurme, Mikko A. Ikram, M. Arfan Jylhä, Marja Kuh, Diana Ligthart, Lannie Lill, Christina M. Lindenberger, Ulman Lumley, Thomas Mägi, Reedik Marques-Vidal, Pedro Medland, Sarah E. Milani, Lili Nagy, Reka Ollier, William E. R. Peyser, Patricia A. Pramstaller, Peter P. Ridker, Paul M. Rivadeneira, Fernando Ruggiero, Daniela Saba, Yasaman Schmidt, Reinhold Schmidt, Helena Slagboom, P. Eline Smith, Blair H. Smith, Jennifer A. Sotoodehnia, Nona Steinhagen-Thiessen, Elisabeth van Rooij, Frank J. A. Verbeek, André L. Vermeulen, Sita H. Vollenweider, Peter Wang, Yunpeng Werge, Thomas Whitfield, John B. Zonderman, Alan B. Lehtimäki, Terho Evans, Michele K. Pirastu, Mario Fuchsberger, Christian Bertram, Lars Pendleton, Neil Kardia, Sharon L. R. Ciullo, Marina Becker, Diane M. Wong, Andrew Psaty, Bruce M. van Duijn, Cornelia M. Wilson, James G. Jukema, J. Wouter Kiemeney, Lambertus Uitterlinden, André G. Franceschini, Nora North, Kari E. Weir, David R. Metspalu, Andres Boomsma, Dorret I. Hayward, Caroline Chasman, Daniel Martin, Nicholas G. Sattar, Naveed Campbell, Harry Esko, Tōnu Kutalik, Zoltán Wilson, James F. |
| author_facet | Joshi, Peter K. Pirastu, Nicola Kentistou, Katherine A. Fischer, Krista Hofer, Edith Schraut, Katharina E. Clark, David W. Nutile, Teresa Barnes, Catriona L. K. Timmers, Paul R. H. J. Shen, Xia Gandin, Ilaria McDaid, Aaron F. Hansen, Thomas Folkmann Gordon, Scott D. Giulianini, Franco Boutin, Thibaud S. Abdellaoui, Abdel Zhao, Wei Medina-Gomez, Carolina Bartz, Traci M. Trompet, Stella Lange, Leslie A. Raffield, Laura van der Spek, Ashley Galesloot, Tessel E. Proitsi, Petroula Yanek, Lisa R. Bielak, Lawrence F. Payton, Antony Murgia, Federico Concas, Maria Pina Biino, Ginevra Tajuddin, Salman M. Seppälä, Ilkka Amin, Najaf Boerwinkle, Eric Børglum, Anders D. Campbell, Archie Demerath, Ellen W. Demuth, Ilja Faul, Jessica D. Ford, Ian Gialluisi, Alessandro Gögele, Martin Graff, MariaElisa Hingorani, Aroon Hottenga, Jouke-Jan Hougaard, David M. Hurme, Mikko A. Ikram, M. Arfan Jylhä, Marja Kuh, Diana Ligthart, Lannie Lill, Christina M. Lindenberger, Ulman Lumley, Thomas Mägi, Reedik Marques-Vidal, Pedro Medland, Sarah E. Milani, Lili Nagy, Reka Ollier, William E. R. Peyser, Patricia A. Pramstaller, Peter P. Ridker, Paul M. Rivadeneira, Fernando Ruggiero, Daniela Saba, Yasaman Schmidt, Reinhold Schmidt, Helena Slagboom, P. Eline Smith, Blair H. Smith, Jennifer A. Sotoodehnia, Nona Steinhagen-Thiessen, Elisabeth van Rooij, Frank J. A. Verbeek, André L. Vermeulen, Sita H. Vollenweider, Peter Wang, Yunpeng Werge, Thomas Whitfield, John B. Zonderman, Alan B. Lehtimäki, Terho Evans, Michele K. Pirastu, Mario Fuchsberger, Christian Bertram, Lars Pendleton, Neil Kardia, Sharon L. R. Ciullo, Marina Becker, Diane M. Wong, Andrew Psaty, Bruce M. van Duijn, Cornelia M. Wilson, James G. Jukema, J. Wouter Kiemeney, Lambertus Uitterlinden, André G. Franceschini, Nora North, Kari E. Weir, David R. Metspalu, Andres Boomsma, Dorret I. Hayward, Caroline Chasman, Daniel Martin, Nicholas G. Sattar, Naveed Campbell, Harry Esko, Tōnu Kutalik, Zoltán Wilson, James F. |
| author_sort | Joshi, Peter K. |
| collection | PubMed |
| description | Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents’ survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHRNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity. Next we show that giving up smoking, educational attainment, openness to new experience and high-density lipoprotein (HDL) cholesterol levels are most positively genetically correlated with lifespan while susceptibility to coronary artery disease (CAD), cigarettes smoked per day, lung cancer, insulin resistance and body fat are most negatively correlated. We suggest that the effect of education on lifespan is principally mediated through smoking while the effect of obesity appears to act via CAD. Using instrumental variables, we suggest that an increase of one body mass index unit reduces lifespan by 7 months while 1 year of education adds 11 months to expected lifespan. |
| format | Online Article Text |
| id | pubmed-5715013 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-57150132017-12-06 Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity Joshi, Peter K. Pirastu, Nicola Kentistou, Katherine A. Fischer, Krista Hofer, Edith Schraut, Katharina E. Clark, David W. Nutile, Teresa Barnes, Catriona L. K. Timmers, Paul R. H. J. Shen, Xia Gandin, Ilaria McDaid, Aaron F. Hansen, Thomas Folkmann Gordon, Scott D. Giulianini, Franco Boutin, Thibaud S. Abdellaoui, Abdel Zhao, Wei Medina-Gomez, Carolina Bartz, Traci M. Trompet, Stella Lange, Leslie A. Raffield, Laura van der Spek, Ashley Galesloot, Tessel E. Proitsi, Petroula Yanek, Lisa R. Bielak, Lawrence F. Payton, Antony Murgia, Federico Concas, Maria Pina Biino, Ginevra Tajuddin, Salman M. Seppälä, Ilkka Amin, Najaf Boerwinkle, Eric Børglum, Anders D. Campbell, Archie Demerath, Ellen W. Demuth, Ilja Faul, Jessica D. Ford, Ian Gialluisi, Alessandro Gögele, Martin Graff, MariaElisa Hingorani, Aroon Hottenga, Jouke-Jan Hougaard, David M. Hurme, Mikko A. Ikram, M. Arfan Jylhä, Marja Kuh, Diana Ligthart, Lannie Lill, Christina M. Lindenberger, Ulman Lumley, Thomas Mägi, Reedik Marques-Vidal, Pedro Medland, Sarah E. Milani, Lili Nagy, Reka Ollier, William E. R. Peyser, Patricia A. Pramstaller, Peter P. Ridker, Paul M. Rivadeneira, Fernando Ruggiero, Daniela Saba, Yasaman Schmidt, Reinhold Schmidt, Helena Slagboom, P. Eline Smith, Blair H. Smith, Jennifer A. Sotoodehnia, Nona Steinhagen-Thiessen, Elisabeth van Rooij, Frank J. A. Verbeek, André L. Vermeulen, Sita H. Vollenweider, Peter Wang, Yunpeng Werge, Thomas Whitfield, John B. Zonderman, Alan B. Lehtimäki, Terho Evans, Michele K. Pirastu, Mario Fuchsberger, Christian Bertram, Lars Pendleton, Neil Kardia, Sharon L. R. Ciullo, Marina Becker, Diane M. Wong, Andrew Psaty, Bruce M. van Duijn, Cornelia M. Wilson, James G. Jukema, J. Wouter Kiemeney, Lambertus Uitterlinden, André G. Franceschini, Nora North, Kari E. Weir, David R. Metspalu, Andres Boomsma, Dorret I. Hayward, Caroline Chasman, Daniel Martin, Nicholas G. Sattar, Naveed Campbell, Harry Esko, Tōnu Kutalik, Zoltán Wilson, James F. Nat Commun Article Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents’ survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHRNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity. Next we show that giving up smoking, educational attainment, openness to new experience and high-density lipoprotein (HDL) cholesterol levels are most positively genetically correlated with lifespan while susceptibility to coronary artery disease (CAD), cigarettes smoked per day, lung cancer, insulin resistance and body fat are most negatively correlated. We suggest that the effect of education on lifespan is principally mediated through smoking while the effect of obesity appears to act via CAD. Using instrumental variables, we suggest that an increase of one body mass index unit reduces lifespan by 7 months while 1 year of education adds 11 months to expected lifespan. Nature Publishing Group UK 2017-10-13 /pmc/articles/PMC5715013/ /pubmed/29030599 http://dx.doi.org/10.1038/s41467-017-00934-5 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Joshi, Peter K. Pirastu, Nicola Kentistou, Katherine A. Fischer, Krista Hofer, Edith Schraut, Katharina E. Clark, David W. Nutile, Teresa Barnes, Catriona L. K. Timmers, Paul R. H. J. Shen, Xia Gandin, Ilaria McDaid, Aaron F. Hansen, Thomas Folkmann Gordon, Scott D. Giulianini, Franco Boutin, Thibaud S. Abdellaoui, Abdel Zhao, Wei Medina-Gomez, Carolina Bartz, Traci M. Trompet, Stella Lange, Leslie A. Raffield, Laura van der Spek, Ashley Galesloot, Tessel E. Proitsi, Petroula Yanek, Lisa R. Bielak, Lawrence F. Payton, Antony Murgia, Federico Concas, Maria Pina Biino, Ginevra Tajuddin, Salman M. Seppälä, Ilkka Amin, Najaf Boerwinkle, Eric Børglum, Anders D. Campbell, Archie Demerath, Ellen W. Demuth, Ilja Faul, Jessica D. Ford, Ian Gialluisi, Alessandro Gögele, Martin Graff, MariaElisa Hingorani, Aroon Hottenga, Jouke-Jan Hougaard, David M. Hurme, Mikko A. Ikram, M. Arfan Jylhä, Marja Kuh, Diana Ligthart, Lannie Lill, Christina M. Lindenberger, Ulman Lumley, Thomas Mägi, Reedik Marques-Vidal, Pedro Medland, Sarah E. Milani, Lili Nagy, Reka Ollier, William E. R. Peyser, Patricia A. Pramstaller, Peter P. Ridker, Paul M. Rivadeneira, Fernando Ruggiero, Daniela Saba, Yasaman Schmidt, Reinhold Schmidt, Helena Slagboom, P. Eline Smith, Blair H. Smith, Jennifer A. Sotoodehnia, Nona Steinhagen-Thiessen, Elisabeth van Rooij, Frank J. A. Verbeek, André L. Vermeulen, Sita H. Vollenweider, Peter Wang, Yunpeng Werge, Thomas Whitfield, John B. Zonderman, Alan B. Lehtimäki, Terho Evans, Michele K. Pirastu, Mario Fuchsberger, Christian Bertram, Lars Pendleton, Neil Kardia, Sharon L. R. Ciullo, Marina Becker, Diane M. Wong, Andrew Psaty, Bruce M. van Duijn, Cornelia M. Wilson, James G. Jukema, J. Wouter Kiemeney, Lambertus Uitterlinden, André G. Franceschini, Nora North, Kari E. Weir, David R. Metspalu, Andres Boomsma, Dorret I. Hayward, Caroline Chasman, Daniel Martin, Nicholas G. Sattar, Naveed Campbell, Harry Esko, Tōnu Kutalik, Zoltán Wilson, James F. Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
| title | Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
| title_full | Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
| title_fullStr | Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
| title_full_unstemmed | Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
| title_short | Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
| title_sort | genome-wide meta-analysis associates hla-dqa1/drb1 and lpa and lifestyle factors with human longevity |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715013/ https://www.ncbi.nlm.nih.gov/pubmed/29030599 http://dx.doi.org/10.1038/s41467-017-00934-5 |
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