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Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

Genomic analysis of longevity offers the potential to illuminate the biology of human aging. Here, using genome-wide association meta-analysis of 606,059 parents’ survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). We also validate previous suggestions that APOE, CHR...

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Detalles Bibliográficos
Autores principales: Joshi, Peter K., Pirastu, Nicola, Kentistou, Katherine A., Fischer, Krista, Hofer, Edith, Schraut, Katharina E., Clark, David W., Nutile, Teresa, Barnes, Catriona L. K., Timmers, Paul R. H. J., Shen, Xia, Gandin, Ilaria, McDaid, Aaron F., Hansen, Thomas Folkmann, Gordon, Scott D., Giulianini, Franco, Boutin, Thibaud S., Abdellaoui, Abdel, Zhao, Wei, Medina-Gomez, Carolina, Bartz, Traci M., Trompet, Stella, Lange, Leslie A., Raffield, Laura, van der Spek, Ashley, Galesloot, Tessel E., Proitsi, Petroula, Yanek, Lisa R., Bielak, Lawrence F., Payton, Antony, Murgia, Federico, Concas, Maria Pina, Biino, Ginevra, Tajuddin, Salman M., Seppälä, Ilkka, Amin, Najaf, Boerwinkle, Eric, Børglum, Anders D., Campbell, Archie, Demerath, Ellen W., Demuth, Ilja, Faul, Jessica D., Ford, Ian, Gialluisi, Alessandro, Gögele, Martin, Graff, MariaElisa, Hingorani, Aroon, Hottenga, Jouke-Jan, Hougaard, David M., Hurme, Mikko A., Ikram, M. Arfan, Jylhä, Marja, Kuh, Diana, Ligthart, Lannie, Lill, Christina M., Lindenberger, Ulman, Lumley, Thomas, Mägi, Reedik, Marques-Vidal, Pedro, Medland, Sarah E., Milani, Lili, Nagy, Reka, Ollier, William E. R., Peyser, Patricia A., Pramstaller, Peter P., Ridker, Paul M., Rivadeneira, Fernando, Ruggiero, Daniela, Saba, Yasaman, Schmidt, Reinhold, Schmidt, Helena, Slagboom, P. Eline, Smith, Blair H., Smith, Jennifer A., Sotoodehnia, Nona, Steinhagen-Thiessen, Elisabeth, van Rooij, Frank J. A., Verbeek, André L., Vermeulen, Sita H., Vollenweider, Peter, Wang, Yunpeng, Werge, Thomas, Whitfield, John B., Zonderman, Alan B., Lehtimäki, Terho, Evans, Michele K., Pirastu, Mario, Fuchsberger, Christian, Bertram, Lars, Pendleton, Neil, Kardia, Sharon L. R., Ciullo, Marina, Becker, Diane M., Wong, Andrew, Psaty, Bruce M., van Duijn, Cornelia M., Wilson, James G., Jukema, J. Wouter, Kiemeney, Lambertus, Uitterlinden, André G., Franceschini, Nora, North, Kari E., Weir, David R., Metspalu, Andres, Boomsma, Dorret I., Hayward, Caroline, Chasman, Daniel, Martin, Nicholas G., Sattar, Naveed, Campbell, Harry, Esko, Tōnu, Kutalik, Zoltán, Wilson, James F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715013/
https://www.ncbi.nlm.nih.gov/pubmed/29030599
http://dx.doi.org/10.1038/s41467-017-00934-5

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