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Genome-wide prediction of DNase I hypersensitivity using gene expression
We evaluate the feasibility of using a biological sample’s transcriptome to predict its genome-wide regulatory element activities measured by DNase I hypersensitivity (DH). We develop BIRD, Big Data Regression for predicting DH, to handle this high-dimensional problem. Applying BIRD to the Encyclope...
Autores principales: | Zhou, Weiqiang, Sherwood, Ben, Ji, Zhicheng, Xue, Yingchao, Du, Fang, Bai, Jiawei, Ying, Mingyao, Ji, Hongkai |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715040/ https://www.ncbi.nlm.nih.gov/pubmed/29051481 http://dx.doi.org/10.1038/s41467-017-01188-x |
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