Reduced cell size, chromosomal aberration and altered proliferation rates are characteristics and confounding factors in the STHdh cell model of Huntington disease

Huntington disease is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the gene encoding the huntingtin protein. Expression of the mutant protein disrupts various intracellular pathways and impairs overall cell function. In particular striatal neurons seem to be most vulnerable...

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Detalles Bibliográficos
Autores principales: Singer, Elisabeth, Walter, Carolin, Weber, Jonasz J., Krahl, Ann-Christin, Mau-Holzmann, Ulrike A., Rischert, Nadine, Riess, Olaf, Clemensson, Laura E., Nguyen, Huu P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715050/
https://www.ncbi.nlm.nih.gov/pubmed/29203806
http://dx.doi.org/10.1038/s41598-017-17275-4

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