Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

Down syndrome (DS) is caused by the triplication of human chromosome 21 and represents the most frequent genetic cause of intellectual disability. The trisomic Ts65Dn mouse model of DS shows synaptic deficits and reproduces the essential cognitive disabilities of the human syndrome. Aerobic exercise...

Descripción completa

Detalles Bibliográficos
Autores principales: Parrini, Martina, Ghezzi, Diego, Deidda, Gabriele, Medrihan, Lucian, Castroflorio, Enrico, Alberti, Micol, Baldelli, Pietro, Cancedda, Laura, Contestabile, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715062/
https://www.ncbi.nlm.nih.gov/pubmed/29203796
http://dx.doi.org/10.1038/s41598-017-17201-8

Ejemplares similares

Ejemplares similares