Cargando…
Adjuvant imatinib for patients with high-risk gastrointestinal stromal tumors: a retrospective cohort study
The duration of adjuvant imatinib for high-risk patients with gastrointestinal stromal tumors (GISTs) is still controversial. Therefore, we retrospectively analyzed the data of high-risk patients with GISTs to investigate the appropriate duration. All 185 patients were divided into 4 groups: <1 y...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715066/ https://www.ncbi.nlm.nih.gov/pubmed/29203825 http://dx.doi.org/10.1038/s41598-017-17266-5 |
_version_ | 1783283684823007232 |
---|---|
author | Zhao, Rui Wang, Yong Huang, Yuqian Cui, Yaping Xia, Lin Chen, Yi Zhuang, Wen Zhou, Yong Wu, Xiaoting |
author_facet | Zhao, Rui Wang, Yong Huang, Yuqian Cui, Yaping Xia, Lin Chen, Yi Zhuang, Wen Zhou, Yong Wu, Xiaoting |
author_sort | Zhao, Rui |
collection | PubMed |
description | The duration of adjuvant imatinib for high-risk patients with gastrointestinal stromal tumors (GISTs) is still controversial. Therefore, we retrospectively analyzed the data of high-risk patients with GISTs to investigate the appropriate duration. All 185 patients were divided into 4 groups: <1 year (Group A), 1–2 years (Group B), 2–3 years (Group C) and >3 years (Group D). The mean recurrence-free survival (RFS) in Groups A, B, and C were 44.3, 62.1, and 86.8 months, respectively (P < 0.001); the mean overall survival (OS) in Groups A, B and C was 75.2, 88.1, and 94.7 months, respectively (P = 0.009). The 5-year RFS in Groups A, B, C, and D was 15%, 26%, 83%, and 100%, respectively (P < 0.001); and the 5-year OS was 64%, 88%, 88%, and 100%, respectively (P < 0.001). The greatest impact on unfavorable outcomes was the tumor mitotic rate (HR, 2.01, 95% CI, 1.38–2.94; P < 0.001). Duration of adjuvant imatinib was the only favorable factor (HR, −0.95, 95% CI, 0.93–0.97; P < 0.001). For high-risk patients with high tumor size or mitotic rate, or non-gastric GISTs, we recommend that more than 3 years of adjuvant imatinib is feasible. |
format | Online Article Text |
id | pubmed-5715066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57150662017-12-08 Adjuvant imatinib for patients with high-risk gastrointestinal stromal tumors: a retrospective cohort study Zhao, Rui Wang, Yong Huang, Yuqian Cui, Yaping Xia, Lin Chen, Yi Zhuang, Wen Zhou, Yong Wu, Xiaoting Sci Rep Article The duration of adjuvant imatinib for high-risk patients with gastrointestinal stromal tumors (GISTs) is still controversial. Therefore, we retrospectively analyzed the data of high-risk patients with GISTs to investigate the appropriate duration. All 185 patients were divided into 4 groups: <1 year (Group A), 1–2 years (Group B), 2–3 years (Group C) and >3 years (Group D). The mean recurrence-free survival (RFS) in Groups A, B, and C were 44.3, 62.1, and 86.8 months, respectively (P < 0.001); the mean overall survival (OS) in Groups A, B and C was 75.2, 88.1, and 94.7 months, respectively (P = 0.009). The 5-year RFS in Groups A, B, C, and D was 15%, 26%, 83%, and 100%, respectively (P < 0.001); and the 5-year OS was 64%, 88%, 88%, and 100%, respectively (P < 0.001). The greatest impact on unfavorable outcomes was the tumor mitotic rate (HR, 2.01, 95% CI, 1.38–2.94; P < 0.001). Duration of adjuvant imatinib was the only favorable factor (HR, −0.95, 95% CI, 0.93–0.97; P < 0.001). For high-risk patients with high tumor size or mitotic rate, or non-gastric GISTs, we recommend that more than 3 years of adjuvant imatinib is feasible. Nature Publishing Group UK 2017-12-04 /pmc/articles/PMC5715066/ /pubmed/29203825 http://dx.doi.org/10.1038/s41598-017-17266-5 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhao, Rui Wang, Yong Huang, Yuqian Cui, Yaping Xia, Lin Chen, Yi Zhuang, Wen Zhou, Yong Wu, Xiaoting Adjuvant imatinib for patients with high-risk gastrointestinal stromal tumors: a retrospective cohort study |
title | Adjuvant imatinib for patients with high-risk gastrointestinal stromal tumors: a retrospective cohort study |
title_full | Adjuvant imatinib for patients with high-risk gastrointestinal stromal tumors: a retrospective cohort study |
title_fullStr | Adjuvant imatinib for patients with high-risk gastrointestinal stromal tumors: a retrospective cohort study |
title_full_unstemmed | Adjuvant imatinib for patients with high-risk gastrointestinal stromal tumors: a retrospective cohort study |
title_short | Adjuvant imatinib for patients with high-risk gastrointestinal stromal tumors: a retrospective cohort study |
title_sort | adjuvant imatinib for patients with high-risk gastrointestinal stromal tumors: a retrospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715066/ https://www.ncbi.nlm.nih.gov/pubmed/29203825 http://dx.doi.org/10.1038/s41598-017-17266-5 |
work_keys_str_mv | AT zhaorui adjuvantimatinibforpatientswithhighriskgastrointestinalstromaltumorsaretrospectivecohortstudy AT wangyong adjuvantimatinibforpatientswithhighriskgastrointestinalstromaltumorsaretrospectivecohortstudy AT huangyuqian adjuvantimatinibforpatientswithhighriskgastrointestinalstromaltumorsaretrospectivecohortstudy AT cuiyaping adjuvantimatinibforpatientswithhighriskgastrointestinalstromaltumorsaretrospectivecohortstudy AT xialin adjuvantimatinibforpatientswithhighriskgastrointestinalstromaltumorsaretrospectivecohortstudy AT chenyi adjuvantimatinibforpatientswithhighriskgastrointestinalstromaltumorsaretrospectivecohortstudy AT zhuangwen adjuvantimatinibforpatientswithhighriskgastrointestinalstromaltumorsaretrospectivecohortstudy AT zhouyong adjuvantimatinibforpatientswithhighriskgastrointestinalstromaltumorsaretrospectivecohortstudy AT wuxiaoting adjuvantimatinibforpatientswithhighriskgastrointestinalstromaltumorsaretrospectivecohortstudy |