Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma

Despite novel therapies, relapse of multiple myeloma (MM) is virtually inevitable. Amplification of chromosome 1q, which harbors the inflammation-responsive RNA editase adenosine deaminase acting on RNA (ADAR)1 gene, occurs in 30–50% of MM patients and portends a poor prognosis. Since adenosine-to-i...

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Detalles Bibliográficos
Autores principales: Lazzari, Elisa, Mondala, Phoebe K., Santos, Nathaniel Delos, Miller, Amber C., Pineda, Gabriel, Jiang, Qingfei, Leu, Heather, Ali, Shawn A., Ganesan, Anusha-Preethi, Wu, Christina N., Costello, Caitlin, Minden, Mark, Chiaramonte, Raffaella, Stewart, A.  Keith, Crews, Leslie A., Jamieson, Catriona H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715072/
https://www.ncbi.nlm.nih.gov/pubmed/29203771
http://dx.doi.org/10.1038/s41467-017-01890-w

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