Structures of PPARγ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs

Peroxisome proliferator-activator receptor (PPAR) γ is a nuclear hormone receptor that regulates glucose homeostasis, lipid metabolism, and adipocyte function. PPARγ is a target for thiazolidinedione (TZD) class of drugs which are widely used for the treatment of type 2 diabetes. Recently, lobeglita...

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Detalles Bibliográficos
Autores principales: Lee, Min A, Tan, Lingchen, Yang, Huiseon, Im, Yeong-Gwan, Im, Young Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715099/
https://www.ncbi.nlm.nih.gov/pubmed/29203903
http://dx.doi.org/10.1038/s41598-017-17082-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715099/
https://www.ncbi.nlm.nih.gov/pubmed/29203903
http://dx.doi.org/10.1038/s41598-017-17082-x

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