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A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality
Disruptions in fear-extinction learning are centrally implicated in a range of stress-related disorders, including anxiety and posttraumatic stress disorder. Given that these disorders frequently begin in childhood/adolescence, an understanding of fear-extinction learning in children is essential fo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715118/ https://www.ncbi.nlm.nih.gov/pubmed/29203805 http://dx.doi.org/10.1038/s41598-017-17131-5 |
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author | Marusak, Hilary A. Peters, Craig A. Hehr, Aneesh Elrahal, Farrah Rabinak, Christine A. |
author_facet | Marusak, Hilary A. Peters, Craig A. Hehr, Aneesh Elrahal, Farrah Rabinak, Christine A. |
author_sort | Marusak, Hilary A. |
collection | PubMed |
description | Disruptions in fear-extinction learning are centrally implicated in a range of stress-related disorders, including anxiety and posttraumatic stress disorder. Given that these disorders frequently begin in childhood/adolescence, an understanding of fear-extinction learning in children is essential for (1) detecting the source of developmental susceptibility, (2) identifying mechanisms leading to pathology, and (3) informing the development and/or more judicious application of treatments for youth. Here, we offer and validate a novel virtual reality paradigm to study threat-related learning and extinction in children that models real-world cues, environments, and fear-inducing events that children are likely to experience, and are linked to the development of fear- and stress-related pathologies. We found that our paradigm is well tolerated in children as young as 6 years, that children show intact fear and extinction learning, and show evidence of divergence in subjective, physiological, and behavioral measures of conditioned fear. The paradigm is available for use in 3-D and in 2-D (e.g., for the MRI scanner) upon request at www.tnp2lab.org. |
format | Online Article Text |
id | pubmed-5715118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57151182017-12-08 A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality Marusak, Hilary A. Peters, Craig A. Hehr, Aneesh Elrahal, Farrah Rabinak, Christine A. Sci Rep Article Disruptions in fear-extinction learning are centrally implicated in a range of stress-related disorders, including anxiety and posttraumatic stress disorder. Given that these disorders frequently begin in childhood/adolescence, an understanding of fear-extinction learning in children is essential for (1) detecting the source of developmental susceptibility, (2) identifying mechanisms leading to pathology, and (3) informing the development and/or more judicious application of treatments for youth. Here, we offer and validate a novel virtual reality paradigm to study threat-related learning and extinction in children that models real-world cues, environments, and fear-inducing events that children are likely to experience, and are linked to the development of fear- and stress-related pathologies. We found that our paradigm is well tolerated in children as young as 6 years, that children show intact fear and extinction learning, and show evidence of divergence in subjective, physiological, and behavioral measures of conditioned fear. The paradigm is available for use in 3-D and in 2-D (e.g., for the MRI scanner) upon request at www.tnp2lab.org. Nature Publishing Group UK 2017-12-04 /pmc/articles/PMC5715118/ /pubmed/29203805 http://dx.doi.org/10.1038/s41598-017-17131-5 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Marusak, Hilary A. Peters, Craig A. Hehr, Aneesh Elrahal, Farrah Rabinak, Christine A. A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality |
title | A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality |
title_full | A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality |
title_fullStr | A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality |
title_full_unstemmed | A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality |
title_short | A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality |
title_sort | novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715118/ https://www.ncbi.nlm.nih.gov/pubmed/29203805 http://dx.doi.org/10.1038/s41598-017-17131-5 |
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