Tools for the cryo-EM gold rush: going from the cryo-EM map to the atomistic model

As cryo-electron microscopy (cryo-EM) enters mainstream structural biology, the demand for fitting methods is high. Here, we review existing flexible fitting methods for cryo-EM. We discuss their importance, potential concerns and assessment strategies. We aim to give readers concrete descriptions o...

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Detalles Bibliográficos
Autores principales: Kim, Doo Nam, Sanbonmatsu, Karissa Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715128/
https://www.ncbi.nlm.nih.gov/pubmed/28963369
http://dx.doi.org/10.1042/BSR20170072
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author Kim, Doo Nam
Sanbonmatsu, Karissa Y.
author_facet Kim, Doo Nam
Sanbonmatsu, Karissa Y.
author_sort Kim, Doo Nam
collection PubMed
description As cryo-electron microscopy (cryo-EM) enters mainstream structural biology, the demand for fitting methods is high. Here, we review existing flexible fitting methods for cryo-EM. We discuss their importance, potential concerns and assessment strategies. We aim to give readers concrete descriptions of cryo-EM flexible fitting methods with corresponding examples.
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spelling pubmed-57151282017-12-08 Tools for the cryo-EM gold rush: going from the cryo-EM map to the atomistic model Kim, Doo Nam Sanbonmatsu, Karissa Y. Biosci Rep Review Articles As cryo-electron microscopy (cryo-EM) enters mainstream structural biology, the demand for fitting methods is high. Here, we review existing flexible fitting methods for cryo-EM. We discuss their importance, potential concerns and assessment strategies. We aim to give readers concrete descriptions of cryo-EM flexible fitting methods with corresponding examples. Portland Press Ltd. 2017-12-05 /pmc/articles/PMC5715128/ /pubmed/28963369 http://dx.doi.org/10.1042/BSR20170072 Text en © 2017 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Kim, Doo Nam
Sanbonmatsu, Karissa Y.
Tools for the cryo-EM gold rush: going from the cryo-EM map to the atomistic model
title Tools for the cryo-EM gold rush: going from the cryo-EM map to the atomistic model
title_full Tools for the cryo-EM gold rush: going from the cryo-EM map to the atomistic model
title_fullStr Tools for the cryo-EM gold rush: going from the cryo-EM map to the atomistic model
title_full_unstemmed Tools for the cryo-EM gold rush: going from the cryo-EM map to the atomistic model
title_short Tools for the cryo-EM gold rush: going from the cryo-EM map to the atomistic model
title_sort tools for the cryo-em gold rush: going from the cryo-em map to the atomistic model
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715128/
https://www.ncbi.nlm.nih.gov/pubmed/28963369
http://dx.doi.org/10.1042/BSR20170072
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