Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation

[Image: see text] α-Ketoamides undergo redox-annulations with cyclic secondary amines, such as 1,2,3,4-tetrahydroisoquinoline, pyrrolidine, piperidine, and morpholine. Catalytic amounts of benzoic acid significantly accelerate these transformations. This approach provides polycyclic imidazolidinone...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Zhengbo, Lv, Xin, Anesini, Jason E., Seidel, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715285/
https://www.ncbi.nlm.nih.gov/pubmed/29144764
http://dx.doi.org/10.1021/acs.orglett.7b03309
_version_ 1783283736021827584
author Zhu, Zhengbo
Lv, Xin
Anesini, Jason E.
Seidel, Daniel
author_facet Zhu, Zhengbo
Lv, Xin
Anesini, Jason E.
Seidel, Daniel
author_sort Zhu, Zhengbo
collection PubMed
description [Image: see text] α-Ketoamides undergo redox-annulations with cyclic secondary amines, such as 1,2,3,4-tetrahydroisoquinoline, pyrrolidine, piperidine, and morpholine. Catalytic amounts of benzoic acid significantly accelerate these transformations. This approach provides polycyclic imidazolidinone derivatives in typically good yields.
format Online
Article
Text
id pubmed-5715285
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-57152852017-12-06 Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation Zhu, Zhengbo Lv, Xin Anesini, Jason E. Seidel, Daniel Org Lett [Image: see text] α-Ketoamides undergo redox-annulations with cyclic secondary amines, such as 1,2,3,4-tetrahydroisoquinoline, pyrrolidine, piperidine, and morpholine. Catalytic amounts of benzoic acid significantly accelerate these transformations. This approach provides polycyclic imidazolidinone derivatives in typically good yields. American Chemical Society 2017-11-16 2017-12-01 /pmc/articles/PMC5715285/ /pubmed/29144764 http://dx.doi.org/10.1021/acs.orglett.7b03309 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Zhu, Zhengbo
Lv, Xin
Anesini, Jason E.
Seidel, Daniel
Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation
title Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation
title_full Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation
title_fullStr Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation
title_full_unstemmed Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation
title_short Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation
title_sort synthesis of polycyclic imidazolidinones via amine redox-annulation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715285/
https://www.ncbi.nlm.nih.gov/pubmed/29144764
http://dx.doi.org/10.1021/acs.orglett.7b03309
work_keys_str_mv AT zhuzhengbo synthesisofpolycyclicimidazolidinonesviaamineredoxannulation
AT lvxin synthesisofpolycyclicimidazolidinonesviaamineredoxannulation
AT anesinijasone synthesisofpolycyclicimidazolidinonesviaamineredoxannulation
AT seideldaniel synthesisofpolycyclicimidazolidinonesviaamineredoxannulation

Ejemplares similares