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Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing

Neutrophils are the most abundant leukocytes in human blood. Upon microbial infection, they are massively and rapidly recruited from the circulation to sites of infection where they efficiently kill pathogens. To this end, neutrophils possess a variety of weapons that can be mobilized and become eff...

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Autores principales: Regli, Ivo B., Passelli, Katiuska, Hurrell, Benjamin P., Tacchini-Cottier, Fabienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715327/
https://www.ncbi.nlm.nih.gov/pubmed/29250059
http://dx.doi.org/10.3389/fimmu.2017.01558
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author Regli, Ivo B.
Passelli, Katiuska
Hurrell, Benjamin P.
Tacchini-Cottier, Fabienne
author_facet Regli, Ivo B.
Passelli, Katiuska
Hurrell, Benjamin P.
Tacchini-Cottier, Fabienne
author_sort Regli, Ivo B.
collection PubMed
description Neutrophils are the most abundant leukocytes in human blood. Upon microbial infection, they are massively and rapidly recruited from the circulation to sites of infection where they efficiently kill pathogens. To this end, neutrophils possess a variety of weapons that can be mobilized and become effective within hours following infection. However, several microbes including some Leishmania spp. have evolved a variety of mechanisms to escape neutrophil killing using these cells as a basis to better invade the host. In addition, neutrophils are also present in unhealing cutaneous lesions where their role remains to be defined. Here, we will review recent progress in the field and discuss the different strategies applied by some Leishmania parasites to escape from being killed by neutrophils and as recently described for Leishmania mexicana, even replicate within these cells. Subversion of neutrophil killing functions by Leishmania is a strategy that allows parasite spreading in the host with a consequent deleterious impact, transforming the primary protective role of neutrophils into a deleterious one.
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spelling pubmed-57153272017-12-15 Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing Regli, Ivo B. Passelli, Katiuska Hurrell, Benjamin P. Tacchini-Cottier, Fabienne Front Immunol Immunology Neutrophils are the most abundant leukocytes in human blood. Upon microbial infection, they are massively and rapidly recruited from the circulation to sites of infection where they efficiently kill pathogens. To this end, neutrophils possess a variety of weapons that can be mobilized and become effective within hours following infection. However, several microbes including some Leishmania spp. have evolved a variety of mechanisms to escape neutrophil killing using these cells as a basis to better invade the host. In addition, neutrophils are also present in unhealing cutaneous lesions where their role remains to be defined. Here, we will review recent progress in the field and discuss the different strategies applied by some Leishmania parasites to escape from being killed by neutrophils and as recently described for Leishmania mexicana, even replicate within these cells. Subversion of neutrophil killing functions by Leishmania is a strategy that allows parasite spreading in the host with a consequent deleterious impact, transforming the primary protective role of neutrophils into a deleterious one. Frontiers Media S.A. 2017-11-16 /pmc/articles/PMC5715327/ /pubmed/29250059 http://dx.doi.org/10.3389/fimmu.2017.01558 Text en Copyright © 2017 Regli, Passelli, Hurrell and Tacchini-Cottier. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Regli, Ivo B.
Passelli, Katiuska
Hurrell, Benjamin P.
Tacchini-Cottier, Fabienne
Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing
title Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing
title_full Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing
title_fullStr Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing
title_full_unstemmed Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing
title_short Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing
title_sort survival mechanisms used by some leishmania species to escape neutrophil killing
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715327/
https://www.ncbi.nlm.nih.gov/pubmed/29250059
http://dx.doi.org/10.3389/fimmu.2017.01558
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