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Checkpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract
Monoclonal antibodies targeting the regulatory immune “checkpoint” receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regu...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715331/ https://www.ncbi.nlm.nih.gov/pubmed/29230210 http://dx.doi.org/10.3389/fimmu.2017.01547 |