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Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma

BACKGROUND: Chemoresistance of glioblastoma (GBM) is a feature of this devastating disease. This study is to determine the relationship between Hedgehog (HH)/Gli1 signaling pathway and chemoresistance to temozolomide (TMZ) in human GBM. METHODS: We analyzed Gli1 nuclear staining and O(6)-methylguani...

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Detalles Bibliográficos
Autores principales:	Wang, Ke, Chen, Dongjiang, Qian, Zhouqi, Cui, Daming, Gao, Liang, Lou, Meiqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715541/ https://www.ncbi.nlm.nih.gov/pubmed/29225516 http://dx.doi.org/10.1186/s12935-017-0491-x

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