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Comparison between brain natriuretic peptide and calcitonin gene-related peptide in children with dilated cardiomyopathy and controls

BACKGROUND: Dilated cardiomyopathy (DCM) is revealed with the left ventricular dilatation and systolic dysfunction. OBJECTIVE: This study was performed to determine the level of calcitonin gene-related peptide (CGRP) and brain natriuretic peptide (BNP) in children with DCM and controls and compariso...

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Autores principales: Noori, Noor Mohammad, Teimouri, Alireza, Shahramian, Iraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715565/
https://www.ncbi.nlm.nih.gov/pubmed/29238127
http://dx.doi.org/10.4103/0300-1652.218413
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author Noori, Noor Mohammad
Teimouri, Alireza
Shahramian, Iraj
author_facet Noori, Noor Mohammad
Teimouri, Alireza
Shahramian, Iraj
author_sort Noori, Noor Mohammad
collection PubMed
description BACKGROUND: Dilated cardiomyopathy (DCM) is revealed with the left ventricular dilatation and systolic dysfunction. OBJECTIVE: This study was performed to determine the level of calcitonin gene-related peptide (CGRP) and brain natriuretic peptide (BNP) in children with DCM and controls and comparison of these two biomarkers in patients. MATERIALS AND METHODS: This study was performed from April 2014 to March 2015 on patients with DCM. The levels of BNP and CGRP were measured by ELISA, and final amounts of biomarkers were compared with the echocardiographic finding. RESULTS: In this study, the mean age was 10.567 ± 5.50 and 12.135 ± 4.626 years for controls and cases, respectively (P = 0.321). The majority of echocardiographic indices in the left and right heart had different means in cases and controls (P < 0.05). Means of BNP were 213.814 ± 309.601 and 2.76 ± 1.013 for case and control, respectively (P < 0.001). Means of CGRP were 2.278 ± 1.586 and 1.488 ± 0.501 for cases and controls, respectively, (P = 0.001). In the patients group, however, no significant relationship was observed between CGRP level and Ross classification but observed a direct relationship of Ross classification with BNP (χ(2) = 15.845, P < 0.05). CONCLUSIONS: The present research was performed on DCM patients and showed that most echocardiographic parameters, mean of CGRP and mean of BNP increased in patients compared to healthy children. The severity of illness based on the Ross classification showed significant and positive correlation with BNP level but not with CGRP. Probably, it could be concluded that BNP would be a better biomarker in DCM patients.
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spelling pubmed-57155652017-12-13 Comparison between brain natriuretic peptide and calcitonin gene-related peptide in children with dilated cardiomyopathy and controls Noori, Noor Mohammad Teimouri, Alireza Shahramian, Iraj Niger Med J Original Article BACKGROUND: Dilated cardiomyopathy (DCM) is revealed with the left ventricular dilatation and systolic dysfunction. OBJECTIVE: This study was performed to determine the level of calcitonin gene-related peptide (CGRP) and brain natriuretic peptide (BNP) in children with DCM and controls and comparison of these two biomarkers in patients. MATERIALS AND METHODS: This study was performed from April 2014 to March 2015 on patients with DCM. The levels of BNP and CGRP were measured by ELISA, and final amounts of biomarkers were compared with the echocardiographic finding. RESULTS: In this study, the mean age was 10.567 ± 5.50 and 12.135 ± 4.626 years for controls and cases, respectively (P = 0.321). The majority of echocardiographic indices in the left and right heart had different means in cases and controls (P < 0.05). Means of BNP were 213.814 ± 309.601 and 2.76 ± 1.013 for case and control, respectively (P < 0.001). Means of CGRP were 2.278 ± 1.586 and 1.488 ± 0.501 for cases and controls, respectively, (P = 0.001). In the patients group, however, no significant relationship was observed between CGRP level and Ross classification but observed a direct relationship of Ross classification with BNP (χ(2) = 15.845, P < 0.05). CONCLUSIONS: The present research was performed on DCM patients and showed that most echocardiographic parameters, mean of CGRP and mean of BNP increased in patients compared to healthy children. The severity of illness based on the Ross classification showed significant and positive correlation with BNP level but not with CGRP. Probably, it could be concluded that BNP would be a better biomarker in DCM patients. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5715565/ /pubmed/29238127 http://dx.doi.org/10.4103/0300-1652.218413 Text en Copyright: © 2017 Nigerian Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Noori, Noor Mohammad
Teimouri, Alireza
Shahramian, Iraj
Comparison between brain natriuretic peptide and calcitonin gene-related peptide in children with dilated cardiomyopathy and controls
title Comparison between brain natriuretic peptide and calcitonin gene-related peptide in children with dilated cardiomyopathy and controls
title_full Comparison between brain natriuretic peptide and calcitonin gene-related peptide in children with dilated cardiomyopathy and controls
title_fullStr Comparison between brain natriuretic peptide and calcitonin gene-related peptide in children with dilated cardiomyopathy and controls
title_full_unstemmed Comparison between brain natriuretic peptide and calcitonin gene-related peptide in children with dilated cardiomyopathy and controls
title_short Comparison between brain natriuretic peptide and calcitonin gene-related peptide in children with dilated cardiomyopathy and controls
title_sort comparison between brain natriuretic peptide and calcitonin gene-related peptide in children with dilated cardiomyopathy and controls
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715565/
https://www.ncbi.nlm.nih.gov/pubmed/29238127
http://dx.doi.org/10.4103/0300-1652.218413
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