Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS‐ERG fusion gene

We herein report a rare case of acute basophilic leukemia with t(16;21)(p11;q22) generating the FUS‐ERG fusion gene. The basophilic nature of leukemia blasts was demonstrated by cytomorphology, toluidine blue metachromasia, mature basophil‐associated antigen expression, and characteristic granules u...

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Detalles Bibliográficos
Autores principales: Toda, Yusuke, Nagai, Yuya, Shimomura, Daiki, Kishimori, Chiyuki, Tsuda, Katsuyo, Fukutsuka, Katsuhiro, Hayashida, Masahiko, Ohno, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715573/
https://www.ncbi.nlm.nih.gov/pubmed/29225830
http://dx.doi.org/10.1002/ccr3.1219
Descripción
Sumario:We herein report a rare case of acute basophilic leukemia with t(16;21)(p11;q22) generating the FUS‐ERG fusion gene. The basophilic nature of leukemia blasts was demonstrated by cytomorphology, toluidine blue metachromasia, mature basophil‐associated antigen expression, and characteristic granules under electron microscopy. The molecular link between t(16;21)/FUS‐ERG and basophilic differentiation remains unclear.

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