Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS‐ERG fusion gene

We herein report a rare case of acute basophilic leukemia with t(16;21)(p11;q22) generating the FUS‐ERG fusion gene. The basophilic nature of leukemia blasts was demonstrated by cytomorphology, toluidine blue metachromasia, mature basophil‐associated antigen expression, and characteristic granules u...

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Autores principales: Toda, Yusuke, Nagai, Yuya, Shimomura, Daiki, Kishimori, Chiyuki, Tsuda, Katsuyo, Fukutsuka, Katsuhiro, Hayashida, Masahiko, Ohno, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715573/
https://www.ncbi.nlm.nih.gov/pubmed/29225830
http://dx.doi.org/10.1002/ccr3.1219
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author Toda, Yusuke
Nagai, Yuya
Shimomura, Daiki
Kishimori, Chiyuki
Tsuda, Katsuyo
Fukutsuka, Katsuhiro
Hayashida, Masahiko
Ohno, Hitoshi
author_facet Toda, Yusuke
Nagai, Yuya
Shimomura, Daiki
Kishimori, Chiyuki
Tsuda, Katsuyo
Fukutsuka, Katsuhiro
Hayashida, Masahiko
Ohno, Hitoshi
author_sort Toda, Yusuke
collection PubMed
description We herein report a rare case of acute basophilic leukemia with t(16;21)(p11;q22) generating the FUS‐ERG fusion gene. The basophilic nature of leukemia blasts was demonstrated by cytomorphology, toluidine blue metachromasia, mature basophil‐associated antigen expression, and characteristic granules under electron microscopy. The molecular link between t(16;21)/FUS‐ERG and basophilic differentiation remains unclear.
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spelling pubmed-57155732017-12-08 Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS‐ERG fusion gene Toda, Yusuke Nagai, Yuya Shimomura, Daiki Kishimori, Chiyuki Tsuda, Katsuyo Fukutsuka, Katsuhiro Hayashida, Masahiko Ohno, Hitoshi Clin Case Rep Case Reports We herein report a rare case of acute basophilic leukemia with t(16;21)(p11;q22) generating the FUS‐ERG fusion gene. The basophilic nature of leukemia blasts was demonstrated by cytomorphology, toluidine blue metachromasia, mature basophil‐associated antigen expression, and characteristic granules under electron microscopy. The molecular link between t(16;21)/FUS‐ERG and basophilic differentiation remains unclear. John Wiley and Sons Inc. 2017-10-11 /pmc/articles/PMC5715573/ /pubmed/29225830 http://dx.doi.org/10.1002/ccr3.1219 Text en © 2017 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Toda, Yusuke
Nagai, Yuya
Shimomura, Daiki
Kishimori, Chiyuki
Tsuda, Katsuyo
Fukutsuka, Katsuhiro
Hayashida, Masahiko
Ohno, Hitoshi
Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS‐ERG fusion gene
title Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS‐ERG fusion gene
title_full Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS‐ERG fusion gene
title_fullStr Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS‐ERG fusion gene
title_full_unstemmed Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS‐ERG fusion gene
title_short Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS‐ERG fusion gene
title_sort acute basophilic leukemia associated with the t(16;21)(p11;q22)/fus‐erg fusion gene
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715573/
https://www.ncbi.nlm.nih.gov/pubmed/29225830
http://dx.doi.org/10.1002/ccr3.1219
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