Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen

Pyoderma gangrenosum (PG) is a morbid necrotizing neutrophilic dermatoses for which current treatments are inadequate. Here, we describe the use of a novel noncytotoxic regimen of the deoxycytidine analog decitabine to treat underlying myeloid malignancy causing PG, to thereby produce safe and effec...

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Detalles Bibliográficos
Autores principales: Saleh, Mostafa F. M., Saunthararajah, Yogen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715603/
https://www.ncbi.nlm.nih.gov/pubmed/29225849
http://dx.doi.org/10.1002/ccr3.1221
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author Saleh, Mostafa F. M.
Saunthararajah, Yogen
author_facet Saleh, Mostafa F. M.
Saunthararajah, Yogen
author_sort Saleh, Mostafa F. M.
collection PubMed
description Pyoderma gangrenosum (PG) is a morbid necrotizing neutrophilic dermatoses for which current treatments are inadequate. Here, we describe the use of a novel noncytotoxic regimen of the deoxycytidine analog decitabine to treat underlying myeloid malignancy causing PG, to thereby produce safe and effective resolution of extensive PG.
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spelling pubmed-57156032017-12-08 Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen Saleh, Mostafa F. M. Saunthararajah, Yogen Clin Case Rep Case Reports Pyoderma gangrenosum (PG) is a morbid necrotizing neutrophilic dermatoses for which current treatments are inadequate. Here, we describe the use of a novel noncytotoxic regimen of the deoxycytidine analog decitabine to treat underlying myeloid malignancy causing PG, to thereby produce safe and effective resolution of extensive PG. John Wiley and Sons Inc. 2017-10-31 /pmc/articles/PMC5715603/ /pubmed/29225849 http://dx.doi.org/10.1002/ccr3.1221 Text en © 2017 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Saleh, Mostafa F. M.
Saunthararajah, Yogen
Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen
title Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen
title_full Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen
title_fullStr Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen
title_full_unstemmed Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen
title_short Severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen
title_sort severe pyoderma gangrenosum caused by myelodysplastic syndrome successfully treated with decitabine administered by a noncytotoxic regimen
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715603/
https://www.ncbi.nlm.nih.gov/pubmed/29225849
http://dx.doi.org/10.1002/ccr3.1221
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