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Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life‐saving treatment

Drug‐induced aHUS is rare; however, early diagnosis is vital to reduce morbidity and mortality. With confirmation of the diagnosis, eculizumab appears to be a viable treatment option to suppress the pro‐inflammatory surge. Furthermore, adverse side effects of medications such as carfilzomib and gemc...

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Detalles Bibliográficos
Autores principales: Gosain, Rahul, Gill, Amitoj, Fuqua, Jacob, Volz, Lesley H., Kessans Knable, Mika R., Bycroft, Ryan, Seger, Sarah, Gosain, Rohit, Rios, Jorge A., Chao, Ju‐Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715608/
https://www.ncbi.nlm.nih.gov/pubmed/29225827
http://dx.doi.org/10.1002/ccr3.1214
Descripción
Sumario:Drug‐induced aHUS is rare; however, early diagnosis is vital to reduce morbidity and mortality. With confirmation of the diagnosis, eculizumab appears to be a viable treatment option to suppress the pro‐inflammatory surge. Furthermore, adverse side effects of medications such as carfilzomib and gemcitabine should be considered in the appropriate settings.