Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life‐saving treatment

Drug‐induced aHUS is rare; however, early diagnosis is vital to reduce morbidity and mortality. With confirmation of the diagnosis, eculizumab appears to be a viable treatment option to suppress the pro‐inflammatory surge. Furthermore, adverse side effects of medications such as carfilzomib and gemc...

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Autores principales: Gosain, Rahul, Gill, Amitoj, Fuqua, Jacob, Volz, Lesley H., Kessans Knable, Mika R., Bycroft, Ryan, Seger, Sarah, Gosain, Rohit, Rios, Jorge A., Chao, Ju‐Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715608/
https://www.ncbi.nlm.nih.gov/pubmed/29225827
http://dx.doi.org/10.1002/ccr3.1214
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author Gosain, Rahul
Gill, Amitoj
Fuqua, Jacob
Volz, Lesley H.
Kessans Knable, Mika R.
Bycroft, Ryan
Seger, Sarah
Gosain, Rohit
Rios, Jorge A.
Chao, Ju‐Hsien
author_facet Gosain, Rahul
Gill, Amitoj
Fuqua, Jacob
Volz, Lesley H.
Kessans Knable, Mika R.
Bycroft, Ryan
Seger, Sarah
Gosain, Rohit
Rios, Jorge A.
Chao, Ju‐Hsien
author_sort Gosain, Rahul
collection PubMed
description Drug‐induced aHUS is rare; however, early diagnosis is vital to reduce morbidity and mortality. With confirmation of the diagnosis, eculizumab appears to be a viable treatment option to suppress the pro‐inflammatory surge. Furthermore, adverse side effects of medications such as carfilzomib and gemcitabine should be considered in the appropriate settings.
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spelling pubmed-57156082017-12-08 Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life‐saving treatment Gosain, Rahul Gill, Amitoj Fuqua, Jacob Volz, Lesley H. Kessans Knable, Mika R. Bycroft, Ryan Seger, Sarah Gosain, Rohit Rios, Jorge A. Chao, Ju‐Hsien Clin Case Rep Case Reports Drug‐induced aHUS is rare; however, early diagnosis is vital to reduce morbidity and mortality. With confirmation of the diagnosis, eculizumab appears to be a viable treatment option to suppress the pro‐inflammatory surge. Furthermore, adverse side effects of medications such as carfilzomib and gemcitabine should be considered in the appropriate settings. John Wiley and Sons Inc. 2017-10-09 /pmc/articles/PMC5715608/ /pubmed/29225827 http://dx.doi.org/10.1002/ccr3.1214 Text en © 2017 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Gosain, Rahul
Gill, Amitoj
Fuqua, Jacob
Volz, Lesley H.
Kessans Knable, Mika R.
Bycroft, Ryan
Seger, Sarah
Gosain, Rohit
Rios, Jorge A.
Chao, Ju‐Hsien
Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life‐saving treatment
title Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life‐saving treatment
title_full Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life‐saving treatment
title_fullStr Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life‐saving treatment
title_full_unstemmed Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life‐saving treatment
title_short Gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life‐saving treatment
title_sort gemcitabine and carfilzomib induced thrombotic microangiopathy: eculizumab as a life‐saving treatment
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715608/
https://www.ncbi.nlm.nih.gov/pubmed/29225827
http://dx.doi.org/10.1002/ccr3.1214
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