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The effect of prone and supine treatment positions for the pre-operative treatment of rectal cancer on organ-at-risk sparing and setup reproducibility using volumetric modulated arc therapy
BACKGROUND AND PURPOSE: To compare organ-at-risk doses and setup reproducibility using the prone and supine orientations in volumetric modulated arc therapy (VMAT) for rectal cancer. MATERIALS AND METHODS: Seventeen consecutive rectal cancer patients undergoing preoperative radiation were selected a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715653/ https://www.ncbi.nlm.nih.gov/pubmed/29202879 http://dx.doi.org/10.1186/s13014-017-0918-5 |
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author | Kim, Anthony Karotki, Aliaksandr Presutti, Joe Gonzales, Glen Wong, Shun Chu, William |
author_facet | Kim, Anthony Karotki, Aliaksandr Presutti, Joe Gonzales, Glen Wong, Shun Chu, William |
author_sort | Kim, Anthony |
collection | PubMed |
description | BACKGROUND AND PURPOSE: To compare organ-at-risk doses and setup reproducibility using the prone and supine orientations in volumetric modulated arc therapy (VMAT) for rectal cancer. MATERIALS AND METHODS: Seventeen consecutive rectal cancer patients undergoing preoperative radiation were selected and setup in either the prone (N = 8) or supine (N = 9) position. All patients were treated using posteriorly-applied VMAT. Bladder and small bowel dose and cone beam CT (CBCT) reproducibility metrics were retrospectively collected. RESULTS: Dose metrics for bladder and small bowel did not show significant differences between the prone and supine orientations. The prone data had a trend for smaller irradiated volumes than supine for the small bowel at lower doses—V20 (prone: 135 ± 99 cm(3); supine: 201 ± 162 cm(3)) and V30 (prone: 78 ± 71 cm(3); supine: 105 ± 106 cm(3)). At higher doses, the trend reversed as exemplified by the small bowel V50.4 (prone: 20 ± 28 cm(3); supine: 10 ± 14 cm(3)). CBCT data showed that rotational errors in pitch and roll were significantly larger for the prone vs. supine orientation (pitch: 2.0° ± 1.3° vs. 0.8° ± 1.1° p < 0.001; roll: 1.0° ± 0.9° vs. 0.3° ± 0.5°, p < 0.001). CONCLUSIONS: Bladder and small bowel doses were not significantly different when comparing VMAT plans developed for the prone and supine orientations. The supine orientation demonstrated improved setup reproducibility. |
format | Online Article Text |
id | pubmed-5715653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57156532017-12-08 The effect of prone and supine treatment positions for the pre-operative treatment of rectal cancer on organ-at-risk sparing and setup reproducibility using volumetric modulated arc therapy Kim, Anthony Karotki, Aliaksandr Presutti, Joe Gonzales, Glen Wong, Shun Chu, William Radiat Oncol Research BACKGROUND AND PURPOSE: To compare organ-at-risk doses and setup reproducibility using the prone and supine orientations in volumetric modulated arc therapy (VMAT) for rectal cancer. MATERIALS AND METHODS: Seventeen consecutive rectal cancer patients undergoing preoperative radiation were selected and setup in either the prone (N = 8) or supine (N = 9) position. All patients were treated using posteriorly-applied VMAT. Bladder and small bowel dose and cone beam CT (CBCT) reproducibility metrics were retrospectively collected. RESULTS: Dose metrics for bladder and small bowel did not show significant differences between the prone and supine orientations. The prone data had a trend for smaller irradiated volumes than supine for the small bowel at lower doses—V20 (prone: 135 ± 99 cm(3); supine: 201 ± 162 cm(3)) and V30 (prone: 78 ± 71 cm(3); supine: 105 ± 106 cm(3)). At higher doses, the trend reversed as exemplified by the small bowel V50.4 (prone: 20 ± 28 cm(3); supine: 10 ± 14 cm(3)). CBCT data showed that rotational errors in pitch and roll were significantly larger for the prone vs. supine orientation (pitch: 2.0° ± 1.3° vs. 0.8° ± 1.1° p < 0.001; roll: 1.0° ± 0.9° vs. 0.3° ± 0.5°, p < 0.001). CONCLUSIONS: Bladder and small bowel doses were not significantly different when comparing VMAT plans developed for the prone and supine orientations. The supine orientation demonstrated improved setup reproducibility. BioMed Central 2017-12-05 /pmc/articles/PMC5715653/ /pubmed/29202879 http://dx.doi.org/10.1186/s13014-017-0918-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Kim, Anthony Karotki, Aliaksandr Presutti, Joe Gonzales, Glen Wong, Shun Chu, William The effect of prone and supine treatment positions for the pre-operative treatment of rectal cancer on organ-at-risk sparing and setup reproducibility using volumetric modulated arc therapy |
title | The effect of prone and supine treatment positions for the pre-operative treatment of rectal cancer on organ-at-risk sparing and setup reproducibility using volumetric modulated arc therapy |
title_full | The effect of prone and supine treatment positions for the pre-operative treatment of rectal cancer on organ-at-risk sparing and setup reproducibility using volumetric modulated arc therapy |
title_fullStr | The effect of prone and supine treatment positions for the pre-operative treatment of rectal cancer on organ-at-risk sparing and setup reproducibility using volumetric modulated arc therapy |
title_full_unstemmed | The effect of prone and supine treatment positions for the pre-operative treatment of rectal cancer on organ-at-risk sparing and setup reproducibility using volumetric modulated arc therapy |
title_short | The effect of prone and supine treatment positions for the pre-operative treatment of rectal cancer on organ-at-risk sparing and setup reproducibility using volumetric modulated arc therapy |
title_sort | effect of prone and supine treatment positions for the pre-operative treatment of rectal cancer on organ-at-risk sparing and setup reproducibility using volumetric modulated arc therapy |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715653/ https://www.ncbi.nlm.nih.gov/pubmed/29202879 http://dx.doi.org/10.1186/s13014-017-0918-5 |
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