Cargando…
A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients
Galectin-3 and ST2 are emerging biomarkers involved in myocardial fibrosis. We evaluate the relevance of a multiparametric biomarker approach based on increased serum levels of NT-proBNP, galectin-3, and ST2 in stratifying the prognosis of chronic heart failure (CHF) outpatients. In 315 CHF outpatie...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715710/ https://www.ncbi.nlm.nih.gov/pubmed/29367540 http://dx.doi.org/10.3390/jcdd4030009 |
_version_ | 1783283818131619840 |
---|---|
author | Grande, Dario Leone, Marta Rizzo, Caterina Terlizzese, Paola Parisi, Giuseppe Gioia, Margherita Ilaria Leopizzi, Tiziana Segreto, Antonio Guida, Piero Romito, Roberta Ciccone, Marco Matteo Di Serio, Francesca Iacoviello, Massimo |
author_facet | Grande, Dario Leone, Marta Rizzo, Caterina Terlizzese, Paola Parisi, Giuseppe Gioia, Margherita Ilaria Leopizzi, Tiziana Segreto, Antonio Guida, Piero Romito, Roberta Ciccone, Marco Matteo Di Serio, Francesca Iacoviello, Massimo |
author_sort | Grande, Dario |
collection | PubMed |
description | Galectin-3 and ST2 are emerging biomarkers involved in myocardial fibrosis. We evaluate the relevance of a multiparametric biomarker approach based on increased serum levels of NT-proBNP, galectin-3, and ST2 in stratifying the prognosis of chronic heart failure (CHF) outpatients. In 315 CHF outpatients in stable clinical condition clinical and echocardiographic evaluations were performed. Routine chemistry and serum levels of NT-proBNP, galectin-3, and ST2 were also assessed. During a 12 month follow-up, cardiovascular death, and/or heart failure (HF) occurred in 64 patients. The presence of NT-proBNP, galectin-3, and ST2 were higher than the recommended cutoffs and were all associated with events at univariate Cox regression analysis, as well as in a multivariate analysis including the three biomarkers. When a score based on the number of biomarkers above the recommended cut-offs was used (in a range of 0–3), it was associated with events both with respect to the univariate (HR 2.96, 95% CI 2.21–3.95, p < 0.001, C-index 0.78) and the multivariate (HR 1.52, 95% CI 1.06–2.17, p: 0.023, C-index 0.87) analyses, after correction for the variables of a reference model. Our results suggest that an easy prognostic approach based on the combination of three biomarkers, although with partially-overlapping pathophysiological mechanisms, is able to identify patients with the highest risk of heart failure progression. |
format | Online Article Text |
id | pubmed-5715710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57157102018-01-19 A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients Grande, Dario Leone, Marta Rizzo, Caterina Terlizzese, Paola Parisi, Giuseppe Gioia, Margherita Ilaria Leopizzi, Tiziana Segreto, Antonio Guida, Piero Romito, Roberta Ciccone, Marco Matteo Di Serio, Francesca Iacoviello, Massimo J Cardiovasc Dev Dis Article Galectin-3 and ST2 are emerging biomarkers involved in myocardial fibrosis. We evaluate the relevance of a multiparametric biomarker approach based on increased serum levels of NT-proBNP, galectin-3, and ST2 in stratifying the prognosis of chronic heart failure (CHF) outpatients. In 315 CHF outpatients in stable clinical condition clinical and echocardiographic evaluations were performed. Routine chemistry and serum levels of NT-proBNP, galectin-3, and ST2 were also assessed. During a 12 month follow-up, cardiovascular death, and/or heart failure (HF) occurred in 64 patients. The presence of NT-proBNP, galectin-3, and ST2 were higher than the recommended cutoffs and were all associated with events at univariate Cox regression analysis, as well as in a multivariate analysis including the three biomarkers. When a score based on the number of biomarkers above the recommended cut-offs was used (in a range of 0–3), it was associated with events both with respect to the univariate (HR 2.96, 95% CI 2.21–3.95, p < 0.001, C-index 0.78) and the multivariate (HR 1.52, 95% CI 1.06–2.17, p: 0.023, C-index 0.87) analyses, after correction for the variables of a reference model. Our results suggest that an easy prognostic approach based on the combination of three biomarkers, although with partially-overlapping pathophysiological mechanisms, is able to identify patients with the highest risk of heart failure progression. MDPI 2017-07-15 /pmc/articles/PMC5715710/ /pubmed/29367540 http://dx.doi.org/10.3390/jcdd4030009 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Grande, Dario Leone, Marta Rizzo, Caterina Terlizzese, Paola Parisi, Giuseppe Gioia, Margherita Ilaria Leopizzi, Tiziana Segreto, Antonio Guida, Piero Romito, Roberta Ciccone, Marco Matteo Di Serio, Francesca Iacoviello, Massimo A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients |
title | A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients |
title_full | A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients |
title_fullStr | A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients |
title_full_unstemmed | A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients |
title_short | A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients |
title_sort | multiparametric approach based on nt-probnp, st2, and galectin3 for stratifying one year prognosis of chronic heart failure outpatients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715710/ https://www.ncbi.nlm.nih.gov/pubmed/29367540 http://dx.doi.org/10.3390/jcdd4030009 |
work_keys_str_mv | AT grandedario amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT leonemarta amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT rizzocaterina amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT terlizzesepaola amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT parisigiuseppe amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT gioiamargheritailaria amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT leopizzitiziana amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT segretoantonio amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT guidapiero amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT romitoroberta amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT cicconemarcomatteo amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT diseriofrancesca amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT iacoviellomassimo amultiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT grandedario multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT leonemarta multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT rizzocaterina multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT terlizzesepaola multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT parisigiuseppe multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT gioiamargheritailaria multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT leopizzitiziana multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT segretoantonio multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT guidapiero multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT romitoroberta multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT cicconemarcomatteo multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT diseriofrancesca multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients AT iacoviellomassimo multiparametricapproachbasedonntprobnpst2andgalectin3forstratifyingoneyearprognosisofchronicheartfailureoutpatients |