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A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients

Galectin-3 and ST2 are emerging biomarkers involved in myocardial fibrosis. We evaluate the relevance of a multiparametric biomarker approach based on increased serum levels of NT-proBNP, galectin-3, and ST2 in stratifying the prognosis of chronic heart failure (CHF) outpatients. In 315 CHF outpatie...

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Autores principales: Grande, Dario, Leone, Marta, Rizzo, Caterina, Terlizzese, Paola, Parisi, Giuseppe, Gioia, Margherita Ilaria, Leopizzi, Tiziana, Segreto, Antonio, Guida, Piero, Romito, Roberta, Ciccone, Marco Matteo, Di Serio, Francesca, Iacoviello, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715710/
https://www.ncbi.nlm.nih.gov/pubmed/29367540
http://dx.doi.org/10.3390/jcdd4030009
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author Grande, Dario
Leone, Marta
Rizzo, Caterina
Terlizzese, Paola
Parisi, Giuseppe
Gioia, Margherita Ilaria
Leopizzi, Tiziana
Segreto, Antonio
Guida, Piero
Romito, Roberta
Ciccone, Marco Matteo
Di Serio, Francesca
Iacoviello, Massimo
author_facet Grande, Dario
Leone, Marta
Rizzo, Caterina
Terlizzese, Paola
Parisi, Giuseppe
Gioia, Margherita Ilaria
Leopizzi, Tiziana
Segreto, Antonio
Guida, Piero
Romito, Roberta
Ciccone, Marco Matteo
Di Serio, Francesca
Iacoviello, Massimo
author_sort Grande, Dario
collection PubMed
description Galectin-3 and ST2 are emerging biomarkers involved in myocardial fibrosis. We evaluate the relevance of a multiparametric biomarker approach based on increased serum levels of NT-proBNP, galectin-3, and ST2 in stratifying the prognosis of chronic heart failure (CHF) outpatients. In 315 CHF outpatients in stable clinical condition clinical and echocardiographic evaluations were performed. Routine chemistry and serum levels of NT-proBNP, galectin-3, and ST2 were also assessed. During a 12 month follow-up, cardiovascular death, and/or heart failure (HF) occurred in 64 patients. The presence of NT-proBNP, galectin-3, and ST2 were higher than the recommended cutoffs and were all associated with events at univariate Cox regression analysis, as well as in a multivariate analysis including the three biomarkers. When a score based on the number of biomarkers above the recommended cut-offs was used (in a range of 0–3), it was associated with events both with respect to the univariate (HR 2.96, 95% CI 2.21–3.95, p < 0.001, C-index 0.78) and the multivariate (HR 1.52, 95% CI 1.06–2.17, p: 0.023, C-index 0.87) analyses, after correction for the variables of a reference model. Our results suggest that an easy prognostic approach based on the combination of three biomarkers, although with partially-overlapping pathophysiological mechanisms, is able to identify patients with the highest risk of heart failure progression.
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spelling pubmed-57157102018-01-19 A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients Grande, Dario Leone, Marta Rizzo, Caterina Terlizzese, Paola Parisi, Giuseppe Gioia, Margherita Ilaria Leopizzi, Tiziana Segreto, Antonio Guida, Piero Romito, Roberta Ciccone, Marco Matteo Di Serio, Francesca Iacoviello, Massimo J Cardiovasc Dev Dis Article Galectin-3 and ST2 are emerging biomarkers involved in myocardial fibrosis. We evaluate the relevance of a multiparametric biomarker approach based on increased serum levels of NT-proBNP, galectin-3, and ST2 in stratifying the prognosis of chronic heart failure (CHF) outpatients. In 315 CHF outpatients in stable clinical condition clinical and echocardiographic evaluations were performed. Routine chemistry and serum levels of NT-proBNP, galectin-3, and ST2 were also assessed. During a 12 month follow-up, cardiovascular death, and/or heart failure (HF) occurred in 64 patients. The presence of NT-proBNP, galectin-3, and ST2 were higher than the recommended cutoffs and were all associated with events at univariate Cox regression analysis, as well as in a multivariate analysis including the three biomarkers. When a score based on the number of biomarkers above the recommended cut-offs was used (in a range of 0–3), it was associated with events both with respect to the univariate (HR 2.96, 95% CI 2.21–3.95, p < 0.001, C-index 0.78) and the multivariate (HR 1.52, 95% CI 1.06–2.17, p: 0.023, C-index 0.87) analyses, after correction for the variables of a reference model. Our results suggest that an easy prognostic approach based on the combination of three biomarkers, although with partially-overlapping pathophysiological mechanisms, is able to identify patients with the highest risk of heart failure progression. MDPI 2017-07-15 /pmc/articles/PMC5715710/ /pubmed/29367540 http://dx.doi.org/10.3390/jcdd4030009 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grande, Dario
Leone, Marta
Rizzo, Caterina
Terlizzese, Paola
Parisi, Giuseppe
Gioia, Margherita Ilaria
Leopizzi, Tiziana
Segreto, Antonio
Guida, Piero
Romito, Roberta
Ciccone, Marco Matteo
Di Serio, Francesca
Iacoviello, Massimo
A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients
title A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients
title_full A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients
title_fullStr A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients
title_full_unstemmed A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients
title_short A Multiparametric Approach Based on NT-proBNP, ST2, and Galectin3 for Stratifying One Year Prognosis of Chronic Heart Failure Outpatients
title_sort multiparametric approach based on nt-probnp, st2, and galectin3 for stratifying one year prognosis of chronic heart failure outpatients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715710/
https://www.ncbi.nlm.nih.gov/pubmed/29367540
http://dx.doi.org/10.3390/jcdd4030009
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