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Molecular mechanism of estrogen–estrogen receptor signaling

17β‐Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and estrogen receptor (ER)α and ERβ that are encoded by distinct genes. Localized at the peri‐membrane, mitochon...

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Autores principales: Yaşar, Pelin, Ayaz, Gamze, User, Sırma Damla, Güpür, Gizem, Muyan, Mesut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715874/
https://www.ncbi.nlm.nih.gov/pubmed/29259445
http://dx.doi.org/10.1002/rmb2.12006
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author Yaşar, Pelin
Ayaz, Gamze
User, Sırma Damla
Güpür, Gizem
Muyan, Mesut
author_facet Yaşar, Pelin
Ayaz, Gamze
User, Sırma Damla
Güpür, Gizem
Muyan, Mesut
author_sort Yaşar, Pelin
collection PubMed
description 17β‐Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and estrogen receptor (ER)α and ERβ that are encoded by distinct genes. Localized at the peri‐membrane, mitochondria, and the nucleus of cells that are dependent on estrogen target tissues, the ERs share similar, as well as distinct, regulatory potentials. Different intracellular localizations of the ERs result in dynamically integrated and finely tuned E2 signaling cascades that orchestrate cellular growth, differentiation, and death. The deregulation of E2–ER signaling plays a critical role in the initiation and progression of target tissue malignancies. A better understanding of the complex regulatory mechanisms that underlie ER actions in response to E2 therefore holds a critical trajectory for the development of novel prognostic and therapeutic approaches with substantial impacts on the systemic management of target tissue diseases.
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spelling pubmed-57158742017-12-19 Molecular mechanism of estrogen–estrogen receptor signaling Yaşar, Pelin Ayaz, Gamze User, Sırma Damla Güpür, Gizem Muyan, Mesut Reprod Med Biol Review Articles 17β‐Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and estrogen receptor (ER)α and ERβ that are encoded by distinct genes. Localized at the peri‐membrane, mitochondria, and the nucleus of cells that are dependent on estrogen target tissues, the ERs share similar, as well as distinct, regulatory potentials. Different intracellular localizations of the ERs result in dynamically integrated and finely tuned E2 signaling cascades that orchestrate cellular growth, differentiation, and death. The deregulation of E2–ER signaling plays a critical role in the initiation and progression of target tissue malignancies. A better understanding of the complex regulatory mechanisms that underlie ER actions in response to E2 therefore holds a critical trajectory for the development of novel prognostic and therapeutic approaches with substantial impacts on the systemic management of target tissue diseases. John Wiley and Sons Inc. 2016-12-05 /pmc/articles/PMC5715874/ /pubmed/29259445 http://dx.doi.org/10.1002/rmb2.12006 Text en © 2016 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Articles
Yaşar, Pelin
Ayaz, Gamze
User, Sırma Damla
Güpür, Gizem
Muyan, Mesut
Molecular mechanism of estrogen–estrogen receptor signaling
title Molecular mechanism of estrogen–estrogen receptor signaling
title_full Molecular mechanism of estrogen–estrogen receptor signaling
title_fullStr Molecular mechanism of estrogen–estrogen receptor signaling
title_full_unstemmed Molecular mechanism of estrogen–estrogen receptor signaling
title_short Molecular mechanism of estrogen–estrogen receptor signaling
title_sort molecular mechanism of estrogen–estrogen receptor signaling
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715874/
https://www.ncbi.nlm.nih.gov/pubmed/29259445
http://dx.doi.org/10.1002/rmb2.12006
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