Virulence Factors as Targets for Anticryptococcal Therapy

The global mortality due to cryptococcosis caused by Cryptococcus neoformans or C. gattii is unacceptably high. Currently available therapies are decades old and may be impacted by drug resistance. Therefore, the need for more effective antifungal drugs for cryptococcosis is evident. A number of Cry...

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Detalles Bibliográficos
Autores principales: Azevedo, Renata V. D. M., Rizzo, Juliana, Rodrigues, Marcio L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715936/
https://www.ncbi.nlm.nih.gov/pubmed/29376946
http://dx.doi.org/10.3390/jof2040029
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author Azevedo, Renata V. D. M.
Rizzo, Juliana
Rodrigues, Marcio L.
author_facet Azevedo, Renata V. D. M.
Rizzo, Juliana
Rodrigues, Marcio L.
author_sort Azevedo, Renata V. D. M.
collection PubMed
description The global mortality due to cryptococcosis caused by Cryptococcus neoformans or C. gattii is unacceptably high. Currently available therapies are decades old and may be impacted by drug resistance. Therefore, the need for more effective antifungal drugs for cryptococcosis is evident. A number of Cryptococcus virulence factors have been studied in detail, providing crucial information about the fungal biology and putative molecular targets for antifungals. This review focuses on the use of well-described virulence factors of Cryptococcus as potential anticryptococcal agents.
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spelling pubmed-57159362018-01-19 Virulence Factors as Targets for Anticryptococcal Therapy Azevedo, Renata V. D. M. Rizzo, Juliana Rodrigues, Marcio L. J Fungi (Basel) Review The global mortality due to cryptococcosis caused by Cryptococcus neoformans or C. gattii is unacceptably high. Currently available therapies are decades old and may be impacted by drug resistance. Therefore, the need for more effective antifungal drugs for cryptococcosis is evident. A number of Cryptococcus virulence factors have been studied in detail, providing crucial information about the fungal biology and putative molecular targets for antifungals. This review focuses on the use of well-described virulence factors of Cryptococcus as potential anticryptococcal agents. MDPI 2016-11-30 /pmc/articles/PMC5715936/ /pubmed/29376946 http://dx.doi.org/10.3390/jof2040029 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Azevedo, Renata V. D. M.
Rizzo, Juliana
Rodrigues, Marcio L.
Virulence Factors as Targets for Anticryptococcal Therapy
title Virulence Factors as Targets for Anticryptococcal Therapy
title_full Virulence Factors as Targets for Anticryptococcal Therapy
title_fullStr Virulence Factors as Targets for Anticryptococcal Therapy
title_full_unstemmed Virulence Factors as Targets for Anticryptococcal Therapy
title_short Virulence Factors as Targets for Anticryptococcal Therapy
title_sort virulence factors as targets for anticryptococcal therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715936/
https://www.ncbi.nlm.nih.gov/pubmed/29376946
http://dx.doi.org/10.3390/jof2040029
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