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Innate and Adaptive Immunity to Mucorales

Mucormycosis is an invasive fungal infection characterised by rapid filamentous growth, which leads to angioinvasion, thrombosis, and tissue necrosis. The high mortality rates (50–100%) associated with mucormycosis are reflective of not only the aggressive nature of the infection and the poor therap...

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Autores principales: Ghuman, Harlene, Voelz, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715954/
https://www.ncbi.nlm.nih.gov/pubmed/29371565
http://dx.doi.org/10.3390/jof3030048
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author Ghuman, Harlene
Voelz, Kerstin
author_facet Ghuman, Harlene
Voelz, Kerstin
author_sort Ghuman, Harlene
collection PubMed
description Mucormycosis is an invasive fungal infection characterised by rapid filamentous growth, which leads to angioinvasion, thrombosis, and tissue necrosis. The high mortality rates (50–100%) associated with mucormycosis are reflective of not only the aggressive nature of the infection and the poor therapeutics currently employed, but also the failure of the human immune system to successfully clear the infection. Immune effector interaction with Mucorales is influenced by the developmental stage of the mucormycete spore. In a healthy immune environment, resting spores are resistant to phagocytic killing. Contrarily, swollen spores and hyphae are susceptible to damage and degradation by macrophages and neutrophils. Under the effects of immune suppression, the recruitment and efficacy of macrophage and neutrophil activity against mucormycetes is considerably reduced. Following penetration of the endothelial lining, Mucorales encounter platelets. Platelets adhere to both mucormycete spores and hyphae, and exhibit germination suppression and hyphal damage capacity in vitro. Dendritic cells are activated in response to Mucorales hyphae only, and induce adaptive immunity. It is crucial to further knowledge regarding our immune system’s failure to eradicate resting spores under intact immunity and inhibit fungal growth under immunocompromised conditions, in order to understand mucormycosis pathogenicity and enhance therapeutic strategies for mucormycosis.
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spelling pubmed-57159542018-01-19 Innate and Adaptive Immunity to Mucorales Ghuman, Harlene Voelz, Kerstin J Fungi (Basel) Review Mucormycosis is an invasive fungal infection characterised by rapid filamentous growth, which leads to angioinvasion, thrombosis, and tissue necrosis. The high mortality rates (50–100%) associated with mucormycosis are reflective of not only the aggressive nature of the infection and the poor therapeutics currently employed, but also the failure of the human immune system to successfully clear the infection. Immune effector interaction with Mucorales is influenced by the developmental stage of the mucormycete spore. In a healthy immune environment, resting spores are resistant to phagocytic killing. Contrarily, swollen spores and hyphae are susceptible to damage and degradation by macrophages and neutrophils. Under the effects of immune suppression, the recruitment and efficacy of macrophage and neutrophil activity against mucormycetes is considerably reduced. Following penetration of the endothelial lining, Mucorales encounter platelets. Platelets adhere to both mucormycete spores and hyphae, and exhibit germination suppression and hyphal damage capacity in vitro. Dendritic cells are activated in response to Mucorales hyphae only, and induce adaptive immunity. It is crucial to further knowledge regarding our immune system’s failure to eradicate resting spores under intact immunity and inhibit fungal growth under immunocompromised conditions, in order to understand mucormycosis pathogenicity and enhance therapeutic strategies for mucormycosis. MDPI 2017-09-05 /pmc/articles/PMC5715954/ /pubmed/29371565 http://dx.doi.org/10.3390/jof3030048 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ghuman, Harlene
Voelz, Kerstin
Innate and Adaptive Immunity to Mucorales
title Innate and Adaptive Immunity to Mucorales
title_full Innate and Adaptive Immunity to Mucorales
title_fullStr Innate and Adaptive Immunity to Mucorales
title_full_unstemmed Innate and Adaptive Immunity to Mucorales
title_short Innate and Adaptive Immunity to Mucorales
title_sort innate and adaptive immunity to mucorales
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715954/
https://www.ncbi.nlm.nih.gov/pubmed/29371565
http://dx.doi.org/10.3390/jof3030048
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