Human stem cell–derived astrocytes replicate human prions in a PRNP genotype–dependent manner

Prions are infectious agents that cause neurodegenerative diseases such as Creutzfeldt–Jakob disease (CJD). The absence of a human cell culture model that replicates human prions has hampered prion disease research for decades. In this paper, we show that astrocytes derived from human induced plurip...

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Detalles Bibliográficos
Autores principales: Krejciova, Zuzana, Alibhai, James, Zhao, Chen, Krencik, Robert, Rzechorzek, Nina M., Ullian, Erik M., Manson, Jean, Ironside, James W., Head, Mark W., Chandran, Siddharthan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716027/
https://www.ncbi.nlm.nih.gov/pubmed/29141869
http://dx.doi.org/10.1084/jem.20161547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716027/
https://www.ncbi.nlm.nih.gov/pubmed/29141869
http://dx.doi.org/10.1084/jem.20161547

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