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Bim suppresses the development of SLE by limiting myeloid inflammatory responses

The Bcl-2 family is considered the guardian of the mitochondrial apoptotic pathway. We demonstrate that Bim acts as a molecular rheostat by controlling macrophage function not only in lymphoid organs but also in end organs, thereby preventing the break in tolerance. Mice lacking Bim in myeloid cells...

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Detalles Bibliográficos
Autores principales:	Tsai, FuNien, Homan, Philip J., Agrawal, Hemant, Misharin, Alexander V., Abdala-Valencia, Hiam, Haines, G. Kenneth, Dominguez, Salina, Bloomfield, Christina L., Saber, Rana, Chang, Anthony, Mohan, Chandra, Hutcheson, Jack, Davidson, Anne, Budinger, G.R. Scott, Bouillet, Philippe, Dorfleutner, Andrea, Stehlik, Christian, Winter, Deborah R., Cuda, Carla M., Perlman, Harris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716039/ https://www.ncbi.nlm.nih.gov/pubmed/29114065 http://dx.doi.org/10.1084/jem.20170479

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