Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

A variant of the autophagy gene ATG16L1 is associated with Crohn’s disease, an inflammatory bowel disease (IBD), and poor survival in allogeneic hematopoietic stem cell transplant recipients. We demonstrate that ATG16L1 in the intestinal epithelium is essential for preventing loss of Paneth cells an...

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Detalles Bibliográficos
Autores principales: Matsuzawa-Ishimoto, Yu, Shono, Yusuke, Gomez, Luis E., Hubbard-Lucey, Vanessa M., Cammer, Michael, Neil, Jessica, Dewan, M. Zahidunnabi, Lieberman, Sophia R., Lazrak, Amina, Marinis, Jill M., Beal, Allison, Harris, Philip A., Bertin, John, Liu, Chen, Ding, Yi, van den Brink, Marcel R.M., Cadwell, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716041/
https://www.ncbi.nlm.nih.gov/pubmed/29089374
http://dx.doi.org/10.1084/jem.20170558

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