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A noncanonical function of cGAMP in inflammasome priming and activation

Recognition of pathogen-associated molecular patterns and danger-associated molecular patterns by host cells is an important step in innate immune activation. The DNA sensor cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) binds to DNA and produces cGAMP, which in turn...

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Detalles Bibliográficos
Autores principales:	Swanson, Karen V., Junkins, Robert D., Kurkjian, Cathryn J., Holley-Guthrie, Elizabeth, Pendse, Avani A., El Morabiti, Rachid, Petrucelli, Alex, Barber, Glen N., Benedict, Chris A., Ting, Jenny P.-Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716045/ https://www.ncbi.nlm.nih.gov/pubmed/29030458 http://dx.doi.org/10.1084/jem.20171749

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