NSD3 keeps IRF3 active

In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20170856) show a novel antiviral innate mechanism by which methyltransferase NSD3 directly monomethylates a transcription factor IRF3 and maintains IRF3 phosphorylation to enhance its transcriptional activity, consequently promoting anti...

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Detalles Bibliográficos
Autores principales: Mino, Takashi, Takeuchi, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716047/
https://www.ncbi.nlm.nih.gov/pubmed/29158375
http://dx.doi.org/10.1084/jem.20171980
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author Mino, Takashi
Takeuchi, Osamu
author_facet Mino, Takashi
Takeuchi, Osamu
author_sort Mino, Takashi
collection PubMed
description In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20170856) show a novel antiviral innate mechanism by which methyltransferase NSD3 directly monomethylates a transcription factor IRF3 and maintains IRF3 phosphorylation to enhance its transcriptional activity, consequently promoting antiviral innate immune responses.
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spelling pubmed-57160472018-06-04 NSD3 keeps IRF3 active Mino, Takashi Takeuchi, Osamu J Exp Med News In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20170856) show a novel antiviral innate mechanism by which methyltransferase NSD3 directly monomethylates a transcription factor IRF3 and maintains IRF3 phosphorylation to enhance its transcriptional activity, consequently promoting antiviral innate immune responses. The Rockefeller University Press 2017-12-04 /pmc/articles/PMC5716047/ /pubmed/29158375 http://dx.doi.org/10.1084/jem.20171980 Text en © 2017 Mino and Takeuchi http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Mino, Takashi
Takeuchi, Osamu
NSD3 keeps IRF3 active
title NSD3 keeps IRF3 active
title_full NSD3 keeps IRF3 active
title_fullStr NSD3 keeps IRF3 active
title_full_unstemmed NSD3 keeps IRF3 active
title_short NSD3 keeps IRF3 active
title_sort nsd3 keeps irf3 active
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716047/
https://www.ncbi.nlm.nih.gov/pubmed/29158375
http://dx.doi.org/10.1084/jem.20171980
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