Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference

RNA interference defends against RNA viruses and retro-elements within an organism's genome. It is triggered by duplex siRNAs, of which one strand is selected to confer sequence-specificity to the RNA induced silencing complex (RISC). In Drosophila, Dicer-2 (Dcr-2) and the double-stranded RNA b...

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Detalles Bibliográficos
Autores principales: Tants, Jan-Niklas, Fesser, Stephanie, Kern, Thomas, Stehle, Ralf, Geerlof, Arie, Wunderlich, Christoph, Juen, Michael, Hartlmüller, Christoph, Böttcher, Romy, Kunzelmann, Stefan, Lange, Oliver, Kreutz, Christoph, Förstemann, Klaus, Sattler, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716069/
https://www.ncbi.nlm.nih.gov/pubmed/29040648
http://dx.doi.org/10.1093/nar/gkx886

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