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PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection

Double strand breaks (DSBs) are one of the most toxic lesions to cells. DSB repair by the canonical non-homologous end-joining (C-EJ) pathway involves minor, if any, processing of the broken DNA-ends, whereas the initiation of DNA resection channels the broken-ends toward DNA repair pathways using v...

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Detalles Bibliográficos
Autores principales:	Fouquin, Alexis, Guirouilh-Barbat, Josée, Lopez, Bernard, Hall, Janet, Amor-Guéret, Mounira, Pennaneach, Vincent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716083/ https://www.ncbi.nlm.nih.gov/pubmed/29036662 http://dx.doi.org/10.1093/nar/gkx881

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