Cargando…

NF90–NF45 is a selective RNA chaperone that rearranges viral and cellular riboswitches: biochemical analysis of a virus host factor activity

The heterodimer NF90–NF45 is an RNA-binding protein complex that modulates the expression of various cellular mRNAs on the post-transcriptional level. Furthermore, it acts as a host factor that supports the replication of several RNA viruses. The molecular mechanisms underlying these activities have...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmidt, Tobias, Friedrich, Susann, Golbik, Ralph Peter, Behrens, Sven-Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716087/ https://www.ncbi.nlm.nih.gov/pubmed/29040738 http://dx.doi.org/10.1093/nar/gkx931

Ejemplares similares

Chaperone activation of the hepadnaviral reverse transcriptase for template RNA binding is established by the Hsp70 and stimulated by the Hsp90 system
por: Stahl, Michael, et al.
Publicado: (2007)

Functional characterization of highly processive protein-primed DNA polymerases from phages Nf and GA-1, endowed with a potent strand displacement capacity
por: Longás, Elisa, et al.
Publicado: (2006)

Mechanism of bacterial gene rearrangement: SprA-catalyzed precise DNA recombination and its directionality control by SprB ensure the gene rearrangement and stable expression of spsM during sporulation in Bacillus subtilis
por: Abe, Kimihiro, et al.
Publicado: (2017)

Structural basis for topoisomerase VI inhibition by the anti-Hsp90 drug radicicol
por: Corbett, Kevin D., et al.
Publicado: (2006)

Genome comparison and context analysis reveals putative mobile forms of restriction–modification systems and related rearrangements
por: Furuta, Yoshikazu, et al.
Publicado: (2010)

HSP90 and Aha1 modulate microRNA maturation through promoting the folding of Dicer1
por: Liu, Xiaochuan, et al.
Publicado: (2022)

A biochemically active MCM-like helicase in Bacillus cereus
por: Samuels, Martin, et al.
Publicado: (2009)

Biochemical and genetic analysis of the role of the viral polymerase in enterovirus recombination
por: Woodman, Andrew, et al.
Publicado: (2016)

Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation
por: Unciuleac, Mihaela-Carmen, et al.
Publicado: (2020)

Biochemical and mechanistic analysis of the cleavage of branched DNA by human ANKLE1
por: Freeman, Alasdair D J, et al.
Publicado: (2023)

Insights into the activation of the helicase Prp43 by biochemical studies and structural mass spectrometry
por: Christian, Henning, et al.
Publicado: (2014)

Biochemical analysis of human PIF1 helicase and functions of its N-terminal domain
por: Gu, Yongqing, et al.
Publicado: (2008)

Mutational and biochemical analysis of the DNA-entry nuclease EndA from Streptococcus pneumoniae
por: Midon, Marika, et al.
Publicado: (2011)

Biochemical studies of the Saccharomyces cerevisiae Mph1 helicase on junction-containing DNA structures
por: Kang, Young-Hoon, et al.
Publicado: (2012)

Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase
por: Ndongwe, Tanyaradzwa P., et al.
Publicado: (2012)

Biochemical characterization of the helicase Sen1 provides new insights into the mechanisms of non-coding transcription termination
por: Han, Zhong, et al.
Publicado: (2017)

Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization
por: Jeong, Soo Lim, et al.
Publicado: (2022)

Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe
por: Hausmann, Stéphane, et al.
Publicado: (2007)

Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase
por: Chen, Jianhong, et al.
Publicado: (2015)

Structural and biochemical insight into the mechanism of dual CpG site binding and methylation by the DNMT3A DNA methyltransferase
por: Emperle, Max, et al.
Publicado: (2021)

Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1
por: Gloor, Jason W., et al.
Publicado: (2012)

Cellular localization and dynamics of the Mrr type IV restriction endonuclease of Escherichia coli
por: Ghosh, Anirban, et al.
Publicado: (2014)

Biochemical and mutagenic analysis of I-CreII reveals distinct but important roles for both the H-N-H and GIY-YIG motifs
por: Corina, Laura E., et al.
Publicado: (2009)

cAMP protein kinase phosphorylates the Mos1 transposase and regulates its activity: evidences from mass spectrometry and biochemical analyses
por: Bouchet, Nicolas, et al.
Publicado: (2014)

Random mutagenesis of a hyperthermophilic archaeon identified tRNA modifications associated with cellular hyperthermotolerance
por: Orita, Izumi, et al.
Publicado: (2019)

Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome
por: Nakata, Yoshihiro, et al.
Publicado: (2023)

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors
por: Schneider, Anna, et al.
Publicado: (2016)

The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization
por: Sealey, David C. F., et al.
Publicado: (2010)

Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns
por: Emperle, Max, et al.
Publicado: (2019)

Biochemical analysis of the substrate specificity and sequence preference of endonuclease IV from bacteriophage T4, a dC-specific endonuclease implicated in restriction of dC-substituted T4 DNA synthesis
por: Hirano, Nobutaka, et al.
Publicado: (2006)

Saccharomyces cerevisiae Ngl3p is an active 3′–5′ exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases
por: Feddersen, Ane, et al.
Publicado: (2012)

Human DNA polymerase β polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity
por: Guo, Zhigang, et al.
Publicado: (2009)

Discovery of natural non-circular permutations in non-coding RNAs
por: Eckert, Iris, et al.
Publicado: (2023)

miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5′ end from the cellular pyrophosphatases, DOM3Z and DUSP11
por: Amador-Cañizares, Yalena, et al.
Publicado: (2018)

DNA cleavage site selection by Type III restriction enzymes provides evidence for head-on protein collisions following 1D bidirectional motion
por: Schwarz, Friedrich W., et al.
Publicado: (2011)

The dynamics of the monomeric restriction endonuclease BcnI during its interaction with DNA
por: Kostiuk, Georgij, et al.
Publicado: (2017)

The RNA polymerase factory: a robotic in vitro assembly platform for high-throughput production of recombinant protein complexes
por: Nottebaum, Sven, et al.
Publicado: (2008)

A thermostable d-polymerase for mirror-image PCR
por: Pech, Andreas, et al.
Publicado: (2017)

Physical and functional interactions between Escherichia coli MutL and the Vsr repair endonuclease
por: Heinze, Roger J., et al.
Publicado: (2009)

Magnesium-binding studies reveal fundamental differences between closely related RNA triphosphatases
por: Soulière, Marie F., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_9m36kfos1ehkj89qopeovcansv