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Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it

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Telomeric repeat binding factor 2 (TRF2) folds human telomeres into loops to prevent unwanted DNA repair and chromosome end-joining. The N-terminal basic domain of TRF2 (B-domain) protects the telomeric displacement loop (D-loop) from cleavage by endonucleases. Repressor activator protein 1 (Rap1) b...

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Detalles Bibliográficos
Autores principales:	Nečasová, Ivona, Janoušková, Eliška, Klumpler, Tomáš, Hofr, Ctirad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716094/ https://www.ncbi.nlm.nih.gov/pubmed/28981702 http://dx.doi.org/10.1093/nar/gkx812

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