Thioflavin T binds dimeric parallel-stranded GA-containing non-G-quadruplex DNAs: a general approach to lighting up double-stranded scaffolds

A molecular rotor thioflavin T (ThT) is usually used as a fluorescent ligand specific for G-quadruplexes. Here, we demonstrate that ThT can tightly bind non-G-quadruplex DNAs with several GA motifs and dimerize them in a parallel double-stranded mode, accompanied by over 100-fold enhancement in the...

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Detalles Bibliográficos
Autores principales: Liu, Shuangna, Peng, Pai, Wang, Huihui, Shi, Lili, Li, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716147/
https://www.ncbi.nlm.nih.gov/pubmed/29059300
http://dx.doi.org/10.1093/nar/gkx942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716147/
https://www.ncbi.nlm.nih.gov/pubmed/29059300
http://dx.doi.org/10.1093/nar/gkx942

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