Cargando…

A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression

Long non-coding RNAs (lncRNAs) have been proven to play important roles in diverse cellular processes including the DNA damage response. Nearly 40% of annotated lncRNAs are transcribed in antisense direction to other genes and have often been implicated in their regulation via transcript- or transcr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goyal, Ashish, Fiškin, Evgenij, Gutschner, Tony, Polycarpou-Schwarz, Maria, Groß, Matthias, Neugebauer, Julia, Gandhi, Minakshi, Caudron-Herger, Maiwen, Benes, Vladimir, Diederichs, Sven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716207/ https://www.ncbi.nlm.nih.gov/pubmed/29059299 http://dx.doi.org/10.1093/nar/gkx952

Ejemplares similares

The lncRNA VELUCT strongly regulates viability of lung cancer cells despite its extremely low abundance
por: Seiler, Jana, et al.
Publicado: (2017)

iRAPs curb antisense transcription in E. coli
por: Magán, Andrés, et al.
Publicado: (2019)

Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction
por: Wang, Lingyan, et al.
Publicado: (2020)

Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs
por: Pfafenrot, Christina, et al.
Publicado: (2021)

Global RNA profiles show target selectivity and physiological effects of peptide-delivered antisense antibiotics
por: Popella, Linda, et al.
Publicado: (2021)

Biophysical characterisation of human LincRNA-p21 sense and antisense Alu inverted repeats
por: D’Souza, Michael H, et al.
Publicado: (2022)

Comprehensive analysis of PNA-based antisense antibiotics targeting various essential genes in uropathogenic Escherichia coli
por: Popella, Linda, et al.
Publicado: (2022)

MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs
por: Sun, Qinyu, et al.
Publicado: (2018)

Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response
por: Luo, Shiqi, et al.
Publicado: (2018)

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells
por: Michaels, Wren E, et al.
Publicado: (2020)

Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39
por: De Bortoli, Francesca, et al.
Publicado: (2019)

Uncoupling of nucleo-cytoplasmic RNA export and localization during stress
por: Hochberg-Laufer, Hodaya, et al.
Publicado: (2019)

Conformational rearrangements upon start codon recognition in human 48S translation initiation complex
por: Yi, Sung-Hui, et al.
Publicado: (2022)

A mechanism underlying position-specific regulation of alternative splicing
por: Hamid, Fursham M., et al.
Publicado: (2017)

Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism
por: Scott, Daniel D., et al.
Publicado: (2017)

The RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells
por: Ouyang, Huiwu, et al.
Publicado: (2017)

The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria
por: Reinhard, Linda, et al.
Publicado: (2017)

Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation
por: Bogorad, Andrew M., et al.
Publicado: (2017)

Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide
por: Tang, Leiming, et al.
Publicado: (2017)

Cdk5rap1-mediated 2-methylthio-N(6)-isopentenyladenosine modification is absent from nuclear-derived RNA species
por: Fakruddin, Md., et al.
Publicado: (2017)

The SMAD3 transcription factor binds complex RNA structures with high affinity
por: Dickey, Thayne H., et al.
Publicado: (2017)

An engineered RNA binding protein with improved splicing regulation
por: Hale, Melissa A, et al.
Publicado: (2018)

Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27(Kip1)
por: Roilo, Martina, et al.
Publicado: (2018)

Viewing pre-60S maturation at a minute’s timescale
por: Zisser, Gertrude, et al.
Publicado: (2018)

Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis
por: Shah, Neelam, et al.
Publicado: (2018)

Viral suppressors of RNAi employ a rapid screening mode to discriminate viral RNA from cellular small RNA
por: Fareh, Mohamed, et al.
Publicado: (2018)

Translational regulation by bacterial small RNAs via an unusual Hfq-dependent mechanism
por: Azam, Muhammad S, et al.
Publicado: (2018)

Contrasting silencing mechanisms of the same target mRNA by two regulatory RNAs in Escherichia coli
por: Lalaouna, David, et al.
Publicado: (2018)

Probing of RNA structures in a positive sense RNA virus reveals selection pressures for structural elements
por: Watters, Kyle E, et al.
Publicado: (2018)

RNA-binding specificity landscapes of designer pentatricopeptide repeat proteins elucidate principles of PPR–RNA interactions
por: Miranda, Rafael G, et al.
Publicado: (2018)

Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P
por: Mariotti, Marco, et al.
Publicado: (2017)

Polycytidylation of mitochondrial mRNAs in Chlamydomonas reinhardtii
por: Salinas-Giegé, Thalia, et al.
Publicado: (2017)

Biogenesis and iron-dependency of ribosomal RNA hydroxylation
por: Kimura, Satoshi, et al.
Publicado: (2017)

Conserved structures formed by heterogeneous RNA sequences drive silencing of an inflammation responsive post-transcriptional operon
por: Basu, Abhijit, et al.
Publicado: (2017)

Distinct roles for the IIId2 sub-domain in pestivirus and picornavirus internal ribosome entry sites
por: Willcocks, Margaret M., et al.
Publicado: (2017)

Tuning RNA folding and function through rational design of junction topology
por: Daher, May, et al.
Publicado: (2017)

A structural map of oncomiR-1 at single-nucleotide resolution
por: Chakraborty, Saikat, et al.
Publicado: (2017)

ALYREF mainly binds to the 5′ and the 3′ regions of the mRNA in vivo
por: Shi, Min, et al.
Publicado: (2017)

The conserved AU dinucleotide at the 5′ end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex
por: Yeh, Chung-Shu, et al.
Publicado: (2017)

In vivo probing of nascent RNA structures reveals principles of cotranscriptional folding
por: Incarnato, Danny, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_8adrkj2njv6u65j7i8cvlvksm8