Identification of coexistence of BRAF V600E mutation and EZH2 gain specifically in melanoma as a promising target for combination therapy

BACKGROUND: Coexistence of enhancer of zeste homolog 2 (EZH2) and BRAF gene aberrations has been described in many cancer types. In this study, we aim to explore the coexistence status of BRAF V600E mutation and the copy number variation of EZH2 and explore the potential of this combination as a the...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Huan, Ma, Meng, Yan, Junya, Xu, Longwen, Yu, Jiayi, Dai, Jie, Xu, Tianxiao, Tang, Huan, Wu, Xiaowen, Li, Siming, Lian, Bin, Mao, Lili, Chi, Zhihong, Cui, Chuanliang, Guo, Jun, Kong, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716227/
https://www.ncbi.nlm.nih.gov/pubmed/29202777
http://dx.doi.org/10.1186/s12967-017-1344-z

Ejemplares similares

Ejemplares similares