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Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT

Isoprenylcysteine carboxyl methyltransferase (ICMT) methylesterifies C-terminal prenylcysteine residues of CaaX proteins and some RAB GTPases. Deficiency of either ICMT or NOTCH1 accelerates pancreatic neoplasia in Pdx1-Cre;LSL-Kras(G12D) mice, suggesting that ICMT is required for NOTCH signaling. W...

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Detalles Bibliográficos
Autores principales:	Court, Helen, Ahearn, Ian M., Amoyel, Marc, Bach, Erika A., Philips, Mark R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716267/ https://www.ncbi.nlm.nih.gov/pubmed/29051265 http://dx.doi.org/10.1083/jcb.201701053

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