Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1

We report several receptor tyrosine kinase (RTK) ligands increase RhoA–guanosine triphosphate (GTP) in untransformed and transformed cell lines and determine this phenomenon depends on the RTKs activating the AKT serine/threonine kinase. The increased RhoA-GTP results from AKT phosphorylating three...

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Detalles Bibliográficos
Autores principales: Tripathi, Brajendra K., Grant, Tiera, Qian, Xiaolan, Zhou, Ming, Mertins, Philipp, Wang, Dunrui, Papageorge, Alex G., Tarasov, Sergey G., Hunter, Kent W., Carr, Steven A., Lowy, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716279/
https://www.ncbi.nlm.nih.gov/pubmed/29114068
http://dx.doi.org/10.1083/jcb.201703105

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