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Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation

The initial step of metastasis is the local invasion of tumor cells into the surrounding tissue. Invadopodia are actin-based protrusions that mediate the matrix degradation necessary for invasion and metastasis of tumor cells. We demonstrate that Rac3 GTPase is critical for integrating the adhesion...

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Detalles Bibliográficos
Autores principales:	Donnelly, Sara K., Cabrera, Ramon, Mao, Serena P.H., Christin, John R., Wu, Bin, Guo, Wenjun, Bravo-Cordero, Jose Javier, Condeelis, John S., Segall, Jeffrey E., Hodgson, Louis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716284/ https://www.ncbi.nlm.nih.gov/pubmed/29061650 http://dx.doi.org/10.1083/jcb.201704048

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