cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice

Proinsulin is synthesized in the endoplasmic reticulum (ER) in pancreatic β cells and transported to the Golgi apparatus for proper processing and secretion into plasma. Defects in insulin biogenesis may cause diabetes. However, the underlying mechanisms for proinsulin transport are still not fully...

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Detalles Bibliográficos
Autores principales: Fan, Junwan, Wang, Yaqing, Liu, Liang, Zhang, Hongsheng, Zhang, Feng, Shi, Lei, Yu, Mei, Gao, Fei, Xu, Zhiheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716288/
https://www.ncbi.nlm.nih.gov/pubmed/29133483
http://dx.doi.org/10.1083/jcb.201705027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716288/
https://www.ncbi.nlm.nih.gov/pubmed/29133483
http://dx.doi.org/10.1083/jcb.201705027

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