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cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice
Proinsulin is synthesized in the endoplasmic reticulum (ER) in pancreatic β cells and transported to the Golgi apparatus for proper processing and secretion into plasma. Defects in insulin biogenesis may cause diabetes. However, the underlying mechanisms for proinsulin transport are still not fully...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716288/ https://www.ncbi.nlm.nih.gov/pubmed/29133483 http://dx.doi.org/10.1083/jcb.201705027 |