Ragulator—a multifaceted regulator of lysosomal signaling and trafficking

The lysosomal Ragulator complex regulates cell metabolism and growth by coordinating the activities of metabolic signaling pathways with nutrient availability. In this issue, Filipek et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703061) and Pu et al. (2017. J. Cell Biol. https://doi.org...

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Detalles Bibliográficos
Autores principales: Colaço, Alexandria, Jäättelä, Marja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716293/
https://www.ncbi.nlm.nih.gov/pubmed/29138253
http://dx.doi.org/10.1083/jcb.201710039
Descripción
Sumario:The lysosomal Ragulator complex regulates cell metabolism and growth by coordinating the activities of metabolic signaling pathways with nutrient availability. In this issue, Filipek et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703061) and Pu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703094) introduce a role for Ragulator in growth factor– and nutrient-regulated lysosomal trafficking.

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