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Diabetic Microagiopathy of Oral Mucosa Depends on Disease Duration and Therapy

BACKGROUND: Diabetes mellitus is a chronic degenerative systemic disease whose prevalence is increasing. This paper aims to evaluate the effects of diabetic microangiopathy, depending on its duration and the type of treatment administered, by using polarized light videocapillaroscopy of the oral muc...

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Autores principales: Scardina, Giuseppe A., Citarrella, Roberto, Messina, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716376/
https://www.ncbi.nlm.nih.gov/pubmed/29176542
http://dx.doi.org/10.12659/MSM.902612
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author Scardina, Giuseppe A.
Citarrella, Roberto
Messina, Pietro
author_facet Scardina, Giuseppe A.
Citarrella, Roberto
Messina, Pietro
author_sort Scardina, Giuseppe A.
collection PubMed
description BACKGROUND: Diabetes mellitus is a chronic degenerative systemic disease whose prevalence is increasing. This paper aims to evaluate the effects of diabetic microangiopathy, depending on its duration and the type of treatment administered, by using polarized light videocapillaroscopy of the oral mucosa. MATERIAL/METHODS: We enrolled 120 subjects: 60 healthy subjects and 60 patients with diabetes mellitus. In turn, patients were divided into 3 subgroups according to the type of diabetes, the duration of the disease, and the type of treatment administered. A videocapillaroscopic examination of the oral mucosa was carried out on the diabetic and healthy subjects. RESULTS: Changes in microcirculation were detected in diabetic patients: at the level of the labial, buccal, and lingual mucosa, the density of the loops is on average reduced; there is an increase in the length and the total diameter of the loops, while the average density of the periodontal capillaries is much higher. The most significant changes were noted in patients who had had type 1 diabetes for more than 10 years and had received insulin therapy. CONCLUSIONS: This study, performed using polarized light videocapillaroscopy, which for the first time was used to analyze the capillaries of the oral mucosa in patients with diabetes, confirms the presence of changes that are instrumentally “objectifiable” and “quantifiable” through the videocapillaroscopic technique. Videocapillaroscopy can be a reliable method in the study and monitoring of complications in patients with type 1 and 2 diabetes mellitus.
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spelling pubmed-57163762017-12-07 Diabetic Microagiopathy of Oral Mucosa Depends on Disease Duration and Therapy Scardina, Giuseppe A. Citarrella, Roberto Messina, Pietro Med Sci Monit Clinical Research BACKGROUND: Diabetes mellitus is a chronic degenerative systemic disease whose prevalence is increasing. This paper aims to evaluate the effects of diabetic microangiopathy, depending on its duration and the type of treatment administered, by using polarized light videocapillaroscopy of the oral mucosa. MATERIAL/METHODS: We enrolled 120 subjects: 60 healthy subjects and 60 patients with diabetes mellitus. In turn, patients were divided into 3 subgroups according to the type of diabetes, the duration of the disease, and the type of treatment administered. A videocapillaroscopic examination of the oral mucosa was carried out on the diabetic and healthy subjects. RESULTS: Changes in microcirculation were detected in diabetic patients: at the level of the labial, buccal, and lingual mucosa, the density of the loops is on average reduced; there is an increase in the length and the total diameter of the loops, while the average density of the periodontal capillaries is much higher. The most significant changes were noted in patients who had had type 1 diabetes for more than 10 years and had received insulin therapy. CONCLUSIONS: This study, performed using polarized light videocapillaroscopy, which for the first time was used to analyze the capillaries of the oral mucosa in patients with diabetes, confirms the presence of changes that are instrumentally “objectifiable” and “quantifiable” through the videocapillaroscopic technique. Videocapillaroscopy can be a reliable method in the study and monitoring of complications in patients with type 1 and 2 diabetes mellitus. International Scientific Literature, Inc. 2017-11-25 /pmc/articles/PMC5716376/ /pubmed/29176542 http://dx.doi.org/10.12659/MSM.902612 Text en © Med Sci Monit, 2017 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Scardina, Giuseppe A.
Citarrella, Roberto
Messina, Pietro
Diabetic Microagiopathy of Oral Mucosa Depends on Disease Duration and Therapy
title Diabetic Microagiopathy of Oral Mucosa Depends on Disease Duration and Therapy
title_full Diabetic Microagiopathy of Oral Mucosa Depends on Disease Duration and Therapy
title_fullStr Diabetic Microagiopathy of Oral Mucosa Depends on Disease Duration and Therapy
title_full_unstemmed Diabetic Microagiopathy of Oral Mucosa Depends on Disease Duration and Therapy
title_short Diabetic Microagiopathy of Oral Mucosa Depends on Disease Duration and Therapy
title_sort diabetic microagiopathy of oral mucosa depends on disease duration and therapy
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716376/
https://www.ncbi.nlm.nih.gov/pubmed/29176542
http://dx.doi.org/10.12659/MSM.902612
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