SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

BACKGROUND: Human innate host defense molecules, surfactant protein A1 (SP-A1), and SP-A2 differentially affect the function and proteome of the alveolar macrophage (AM). We hypothesized that SP-A genes differentially regulate the AM miRNome. METHODS: Humanized transgenic mice expressing SP-A1 and S...

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Detalles Bibliográficos
Autores principales: Noutsios, George T., Thorenoor, Nithyananda, Zhang, Xuesheng, Phelps, David S., Umstead, Todd M., Durrani, Faryal, Floros, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716385/
https://www.ncbi.nlm.nih.gov/pubmed/29202868
http://dx.doi.org/10.1186/s13293-017-0158-2

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