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Dosimetric effects of jaw tracking in step‐and‐shoot intensity‐modulated radiation therapy

The purpose of this work was to determine the dosimetric benefit to normal tissues by tracking the multi‐leaf collimator (MLC) apertures with the photon jaws in step‐and‐shoot intensity‐modulated radiation therapy (IMRT) on the Varian 2100 platform. Radiation treatment plans for ten thoracic, three...

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Autores principales: Joy, Sarah, Starkschall, George, Kry, Stephen, Salehpour, Mohammed, White, R. Allen, Lin, Steven H., Balter, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716418/
https://www.ncbi.nlm.nih.gov/pubmed/22402386
http://dx.doi.org/10.1120/jacmp.v13i2.3707
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author Joy, Sarah
Starkschall, George
Kry, Stephen
Salehpour, Mohammed
White, R. Allen
Lin, Steven H.
Balter, Peter
author_facet Joy, Sarah
Starkschall, George
Kry, Stephen
Salehpour, Mohammed
White, R. Allen
Lin, Steven H.
Balter, Peter
author_sort Joy, Sarah
collection PubMed
description The purpose of this work was to determine the dosimetric benefit to normal tissues by tracking the multi‐leaf collimator (MLC) apertures with the photon jaws in step‐and‐shoot intensity‐modulated radiation therapy (IMRT) on the Varian 2100 platform. Radiation treatment plans for ten thoracic, three pediatric, and three head and neck cancer patients were converted to plans with the jaws tracking each segment's MLC apertures, and compared to the original plans in a commercial radiation treatment planning system (TPS). The change in normal tissue dose was evaluated in the new plan by using the parameters V5, V10, and V20 (volumes receiving 5, 10 and 20 Gy, respectively) in the cumulative dose‐volume histogram for the following structures: total lung minus gross target volume, heart, esophagus, spinal cord, liver, parotids, and brainstem. To validate the accuracy of our beam model, MLC transmission was measured and compared to that predicted by the TPS. The greatest changes between the original and new plans occurred at lower dose levels. In all patients, the reduction in V20 was never more than 6.3% and was typically less than 1%; the maximum reduction in V5 was 16.7% and was typically less than 3%. The variation in normal tissue dose reduction was not predictable, and we found no clear parameters that indicated which patients would benefit most from jaw tracking. Our TPS model of MLC transmission agreed with measurements with absolute transmission differences of less than 0.1% and, thus, uncertainties in the model did not contribute significantly to the uncertainty in the dose determination. We conclude that the amount of dose reduction achieved by collimating the jaws around each MLC aperture in step‐and‐shoot IMRT is probably not clinically significant. PACS numbers: 87.55.D‐ 87.55.de 87.55.dk
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spelling pubmed-57164182018-04-02 Dosimetric effects of jaw tracking in step‐and‐shoot intensity‐modulated radiation therapy Joy, Sarah Starkschall, George Kry, Stephen Salehpour, Mohammed White, R. Allen Lin, Steven H. Balter, Peter J Appl Clin Med Phys Radiation Oncology Physics The purpose of this work was to determine the dosimetric benefit to normal tissues by tracking the multi‐leaf collimator (MLC) apertures with the photon jaws in step‐and‐shoot intensity‐modulated radiation therapy (IMRT) on the Varian 2100 platform. Radiation treatment plans for ten thoracic, three pediatric, and three head and neck cancer patients were converted to plans with the jaws tracking each segment's MLC apertures, and compared to the original plans in a commercial radiation treatment planning system (TPS). The change in normal tissue dose was evaluated in the new plan by using the parameters V5, V10, and V20 (volumes receiving 5, 10 and 20 Gy, respectively) in the cumulative dose‐volume histogram for the following structures: total lung minus gross target volume, heart, esophagus, spinal cord, liver, parotids, and brainstem. To validate the accuracy of our beam model, MLC transmission was measured and compared to that predicted by the TPS. The greatest changes between the original and new plans occurred at lower dose levels. In all patients, the reduction in V20 was never more than 6.3% and was typically less than 1%; the maximum reduction in V5 was 16.7% and was typically less than 3%. The variation in normal tissue dose reduction was not predictable, and we found no clear parameters that indicated which patients would benefit most from jaw tracking. Our TPS model of MLC transmission agreed with measurements with absolute transmission differences of less than 0.1% and, thus, uncertainties in the model did not contribute significantly to the uncertainty in the dose determination. We conclude that the amount of dose reduction achieved by collimating the jaws around each MLC aperture in step‐and‐shoot IMRT is probably not clinically significant. PACS numbers: 87.55.D‐ 87.55.de 87.55.dk John Wiley and Sons Inc. 2012-03-08 /pmc/articles/PMC5716418/ /pubmed/22402386 http://dx.doi.org/10.1120/jacmp.v13i2.3707 Text en © 2012 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Joy, Sarah
Starkschall, George
Kry, Stephen
Salehpour, Mohammed
White, R. Allen
Lin, Steven H.
Balter, Peter
Dosimetric effects of jaw tracking in step‐and‐shoot intensity‐modulated radiation therapy
title Dosimetric effects of jaw tracking in step‐and‐shoot intensity‐modulated radiation therapy
title_full Dosimetric effects of jaw tracking in step‐and‐shoot intensity‐modulated radiation therapy
title_fullStr Dosimetric effects of jaw tracking in step‐and‐shoot intensity‐modulated radiation therapy
title_full_unstemmed Dosimetric effects of jaw tracking in step‐and‐shoot intensity‐modulated radiation therapy
title_short Dosimetric effects of jaw tracking in step‐and‐shoot intensity‐modulated radiation therapy
title_sort dosimetric effects of jaw tracking in step‐and‐shoot intensity‐modulated radiation therapy
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716418/
https://www.ncbi.nlm.nih.gov/pubmed/22402386
http://dx.doi.org/10.1120/jacmp.v13i2.3707
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