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Role of Conformational Dynamics in the Evolution of Retro-Aldolase Activity
[Image: see text] Enzymes exist as ensembles of conformations that are important for function. Tuning these populations of conformational states through mutation enables evolution toward additional activities. Here we computationally evaluate the population shifts induced by distal and active site m...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716449/ https://www.ncbi.nlm.nih.gov/pubmed/29226011 http://dx.doi.org/10.1021/acscatal.7b02954 |