mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay

As model organism-based research shifts from forward to reverse genetics approaches, largely due to the ease of genome editing technology, a low frequency of abnormal phenotypes is being observed in lines with mutations predicted to lead to deleterious effects on the encoded protein. In zebrafish, t...

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Detalles Bibliográficos
Autores principales: Anderson, Jennifer L., Mulligan, Timothy S., Shen, Meng-Chieh, Wang, Hui, Scahill, Catherine M., Tan, Frederick J., Du, Shao J., Busch-Nentwich, Elisabeth M., Farber, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716581/
https://www.ncbi.nlm.nih.gov/pubmed/29161261
http://dx.doi.org/10.1371/journal.pgen.1007105

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