Cargando…
Clinical characteristics and programmed cell death ligand-1 expression in adenocarcinoma in situ and minimally invasive adenocarcinoma of lung
OBJECTIVES: According to the IASLC/ATS/ERS 2011 classification, there are two new conceptions of lung adenocarcinoma, adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), which are very early stages of lung adenocarcinoma. This study aimed to analyze clinical features of AIS and MI...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716692/ https://www.ncbi.nlm.nih.gov/pubmed/29228652 http://dx.doi.org/10.18632/oncotarget.22082 |
_version_ | 1783284001791803392 |
---|---|
author | Yu, Renke He, Zhengfu Lou, Ying Jiang, Hanliang Wu, Yuhui Liu, Zhen Pan, Hongming Han, Weidong |
author_facet | Yu, Renke He, Zhengfu Lou, Ying Jiang, Hanliang Wu, Yuhui Liu, Zhen Pan, Hongming Han, Weidong |
author_sort | Yu, Renke |
collection | PubMed |
description | OBJECTIVES: According to the IASLC/ATS/ERS 2011 classification, there are two new conceptions of lung adenocarcinoma, adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), which are very early stages of lung adenocarcinoma. This study aimed to analyze clinical features of AIS and MIA and determine the expression profile of PD-L1 in AIS and MIA. RESULTS: In all 274 patients, 77 were diagnosed as AIS and 197 as MIA. We accidentally found 4 patients with recurrence, which were all MIA. The median age of the patients at diagnosis was both 52 years. 71.4% were female in AIS as while as 71.1% in MIA. 36.4% patients were observed with ever symptoms in AIS and 28.9% in MIA. 12.9% and 8.6% had smoking history respectively in AIS an MIA. All AIS and MIA cases were PD-L1 negative. There was significant association between symptoms and more mild progression of nodules in chest CT before surgery. MATERIALS AND METHODS: We analyzed some clinical features of 274 patients including age, sex, smoking history, family history, surgery, EGFR mutation, ALK, ROS-1, serum CEA level et al. The expression of PD-L1 was evaluated by immunohistochemical analysis in 37 specimens of MIA and 17 specimens of AIS. CONCLUSIONS: There are no significant differences between AIS and MIA in clinical features. AIS and MIA almost do not express PD-L1 protein and without any lymph node metastasis. The surgery intervention is supposed to be as small as possible. |
format | Online Article Text |
id | pubmed-5716692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57166922017-12-08 Clinical characteristics and programmed cell death ligand-1 expression in adenocarcinoma in situ and minimally invasive adenocarcinoma of lung Yu, Renke He, Zhengfu Lou, Ying Jiang, Hanliang Wu, Yuhui Liu, Zhen Pan, Hongming Han, Weidong Oncotarget Research Paper OBJECTIVES: According to the IASLC/ATS/ERS 2011 classification, there are two new conceptions of lung adenocarcinoma, adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), which are very early stages of lung adenocarcinoma. This study aimed to analyze clinical features of AIS and MIA and determine the expression profile of PD-L1 in AIS and MIA. RESULTS: In all 274 patients, 77 were diagnosed as AIS and 197 as MIA. We accidentally found 4 patients with recurrence, which were all MIA. The median age of the patients at diagnosis was both 52 years. 71.4% were female in AIS as while as 71.1% in MIA. 36.4% patients were observed with ever symptoms in AIS and 28.9% in MIA. 12.9% and 8.6% had smoking history respectively in AIS an MIA. All AIS and MIA cases were PD-L1 negative. There was significant association between symptoms and more mild progression of nodules in chest CT before surgery. MATERIALS AND METHODS: We analyzed some clinical features of 274 patients including age, sex, smoking history, family history, surgery, EGFR mutation, ALK, ROS-1, serum CEA level et al. The expression of PD-L1 was evaluated by immunohistochemical analysis in 37 specimens of MIA and 17 specimens of AIS. CONCLUSIONS: There are no significant differences between AIS and MIA in clinical features. AIS and MIA almost do not express PD-L1 protein and without any lymph node metastasis. The surgery intervention is supposed to be as small as possible. Impact Journals LLC 2017-10-26 /pmc/articles/PMC5716692/ /pubmed/29228652 http://dx.doi.org/10.18632/oncotarget.22082 Text en Copyright: © 2017 Yu et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Yu, Renke He, Zhengfu Lou, Ying Jiang, Hanliang Wu, Yuhui Liu, Zhen Pan, Hongming Han, Weidong Clinical characteristics and programmed cell death ligand-1 expression in adenocarcinoma in situ and minimally invasive adenocarcinoma of lung |
title | Clinical characteristics and programmed cell death ligand-1 expression in adenocarcinoma in situ and minimally invasive adenocarcinoma of lung |
title_full | Clinical characteristics and programmed cell death ligand-1 expression in adenocarcinoma in situ and minimally invasive adenocarcinoma of lung |
title_fullStr | Clinical characteristics and programmed cell death ligand-1 expression in adenocarcinoma in situ and minimally invasive adenocarcinoma of lung |
title_full_unstemmed | Clinical characteristics and programmed cell death ligand-1 expression in adenocarcinoma in situ and minimally invasive adenocarcinoma of lung |
title_short | Clinical characteristics and programmed cell death ligand-1 expression in adenocarcinoma in situ and minimally invasive adenocarcinoma of lung |
title_sort | clinical characteristics and programmed cell death ligand-1 expression in adenocarcinoma in situ and minimally invasive adenocarcinoma of lung |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716692/ https://www.ncbi.nlm.nih.gov/pubmed/29228652 http://dx.doi.org/10.18632/oncotarget.22082 |
work_keys_str_mv | AT yurenke clinicalcharacteristicsandprogrammedcelldeathligand1expressioninadenocarcinomainsituandminimallyinvasiveadenocarcinomaoflung AT hezhengfu clinicalcharacteristicsandprogrammedcelldeathligand1expressioninadenocarcinomainsituandminimallyinvasiveadenocarcinomaoflung AT louying clinicalcharacteristicsandprogrammedcelldeathligand1expressioninadenocarcinomainsituandminimallyinvasiveadenocarcinomaoflung AT jianghanliang clinicalcharacteristicsandprogrammedcelldeathligand1expressioninadenocarcinomainsituandminimallyinvasiveadenocarcinomaoflung AT wuyuhui clinicalcharacteristicsandprogrammedcelldeathligand1expressioninadenocarcinomainsituandminimallyinvasiveadenocarcinomaoflung AT liuzhen clinicalcharacteristicsandprogrammedcelldeathligand1expressioninadenocarcinomainsituandminimallyinvasiveadenocarcinomaoflung AT panhongming clinicalcharacteristicsandprogrammedcelldeathligand1expressioninadenocarcinomainsituandminimallyinvasiveadenocarcinomaoflung AT hanweidong clinicalcharacteristicsandprogrammedcelldeathligand1expressioninadenocarcinomainsituandminimallyinvasiveadenocarcinomaoflung |