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Metformin ameliorates skeletal muscle insulin resistance by inhibiting miR-21 expression in a high-fat dietary rat model

Insulin resistance (IR) plays a major role in the pathogenesis of abdominal obesity, hypertension, coronary heart disease, atherosclerosis and diabetes. miR-21 and TGF-β/smads is closely related to IR. However, it remained elusive whether metformin improved skeletal muscle insulin resistance (IRSM)...

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Detalles Bibliográficos
Autores principales:	Wang, Jinyang, Gao, Yanbin, Duan, Lijun, Wei, Suhong, Liu, Jing, Tian, Liming, Quan, Jinxing, Zhang, Qi, Liu, Juxiang, Yang, Jinkui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716711/ https://www.ncbi.nlm.nih.gov/pubmed/29228671 http://dx.doi.org/10.18632/oncotarget.20442

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